PMID- 20134275
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20181030
IS  - 1525-1438 (Electronic)
IS  - 1048-891X (Linking)
VI  - 20
IP  - 2
DP  - 2010 Feb
TI  - Subcutaneous methylnaltrexone to restore postoperative bowel function in a 
      long-term opiate user.
PG  - 308-10
LID - 10.1111/IGC.0b013e3181cd1828 [doi]
AB  - INTRODUCTION: One of the most common undesired effects of analgesic opioid use 
      and addiction is constipation. Numerous pharmacologic agents have been used to 
      treat opioid-induced bowel hypomotility with limited success. Methylnaltrexone 
      bromide (MNTX) selectively targets the peripheral adverse effects of opioids 
      while preserving the central analgesic effects of opioid agonist treatment. CASE: 
      While it is indicated for use in nonsurgical patients in the palliative care 
      setting, here we report the use of MNTX for the alleviation of postoperative 
      ileus in a heroin user with recurrent cervical cancer undergoing diverting 
      colostomy and urinary conduit placement. CONCLUSIONS: Results suggest that MNTX 
      may accelerate postoperative gastrointestinal recovery in opioid-dependent 
      patients. Further studies are warranted to evaluate its role in the pharmacologic 
      management of postoperative ileus.
FAU - Ladanyi, Andras
AU  - Ladanyi A
AD  - Department of Obstetrics and Gynecology, The University of Chicago, Chicago, IL, 
      USA.
FAU - Temkin, Sarah M
AU  - Temkin SM
FAU - Moss, Jonathan
AU  - Moss J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the 
      International Gynecological Cancer Society
JID - 9111626
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0RK7M7IABE (methylnaltrexone)
RN  - 5S6W795CQM (Naltrexone)
SB  - IM
MH  - Analgesics, Opioid/*adverse effects
MH  - Female
MH  - Heroin Dependence/complications
MH  - Humans
MH  - Ileus/chemically induced/*drug therapy
MH  - Injections, Subcutaneous
MH  - Middle Aged
MH  - Naltrexone/*analogs & derivatives/therapeutic use
MH  - Narcotic Antagonists/*therapeutic use
MH  - Postoperative Complications/*drug therapy
MH  - Quaternary Ammonium Compounds/therapeutic use
EDAT- 2010/02/06 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/02/06 06:00
PHST- 2010/02/06 06:00 [entrez]
PHST- 2010/02/06 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 00009577-201002000-00019 [pii]
AID - 10.1111/IGC.0b013e3181cd1828 [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2010 Feb;20(2):308-10. doi: 10.1111/IGC.0b013e3181cd1828.