PMID- 2013615
OWN - NLM
STAT- MEDLINE
DCOM- 19910513
LR  - 20190824
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 32
IP  - 2
DP  - 1991 May
TI  - Active production of anti-human T-lymphotropic virus type I (HTLV-I) IgM antibody 
      in HTLV-I-associated myelopathy.
PG  - 105-9
AB  - We investigated the presence of anti-human T-lymphotropic virus type I (HTLV-I) 
      IgM in sera and cerebrospinal fluid from patients with HTLV-I-associated 
      myelopathy (HAM) by Western blot analysis. Analyses of 36 serum samples revealed 
      that most patients (31/36; 86.1%) had anti-HTLV-I IgM, whereas only four of 23 
      (17.4%) HTLV-I carriers had it. In studies of cerebrospinal fluid, anti-HTLV-I 
      IgM was detected in 24 of 36 (66.7%) HAM patients, whereas none was detected in 
      nine HTLV-I carriers. The differences were statistically significant (p less than 
      0.01). These results suggest that persistent active replication of HTLV-I occurs 
      in the central nervous system as well as in the peripheral blood of HAM patients, 
      and may contribute to the development of HAM.
FAU - Nagasato, K
AU  - Nagasato K
AD  - First Department of Internal Medicine, Nagasaki University School of Medicine, 
      Japan.
FAU - Nakamura, T
AU  - Nakamura T
FAU - Ohishi, K
AU  - Ohishi K
FAU - Shibayama, K
AU  - Shibayama K
FAU - Motomura, M
AU  - Motomura M
FAU - Ichinose, K
AU  - Ichinose K
FAU - Tsujihata, M
AU  - Tsujihata M
FAU - Nagataki, S
AU  - Nagataki S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*blood/cerebrospinal fluid
MH  - Carrier State/blood/cerebrospinal fluid/immunology
MH  - Female
MH  - Human T-lymphotropic virus 1/*immunology
MH  - Humans
MH  - Immunoglobulin M/*analysis
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/blood/cerebrospinal fluid/*immunology
EDAT- 1991/05/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1991/05/01 00:00
PHST- 1991/05/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1991/05/01 00:00 [entrez]
AID - 0165-5728(91)90002-O [pii]
AID - 10.1016/0165-5728(91)90002-o [doi]
PST - ppublish
SO  - J Neuroimmunol. 1991 May;32(2):105-9. doi: 10.1016/0165-5728(91)90002-o.