PMID- 20136773
OWN - NLM
STAT- MEDLINE
DCOM- 20100924
LR  - 20111117
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 75
IP  - 6
DP  - 2010 Jun
TI  - HLA class II polymorphisms in Tunisian patients with dilated cardiomyopathy.
PG  - 679-83
LID - 10.1111/j.1399-0039.2009.01432.x [doi]
AB  - Cardiomyopathies (CMs) are primary disorders of cardiac muscle. They are a major 
      cause of morbidity and mortality for all ages and, like acquired forms of 
      cardiovascular disease, often result in heart failure. Molecular genetic studies 
      have made remarkable progress in defining the pathogenesis of CM. The present 
      study was the first report to evaluate the relationship between class II major 
      histocompatibility complex (MHC) genes (HLA-DRB1 and HLA-DQB1) and the genetic 
      susceptibility to primary dilated cardiomyopathy (DCM) in Tunisian patients. The 
      human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles were analyzed in 76 patients 
      with primary DCM and 111 ethnically matched healthy controls using polymerase 
      chain reaction-sequence specific primers technique. An increased frequencies of 
      HLA-DRB1*0401 (OR = 2.67, P < 0.001), HLA-DQB1*0302 (OR = 3.28, P = 0.001) and 
      HLA-DQB1*0401 (OR = 6.26, P = 0.005) alleles were found in the patients with 
      primary DCM compared with healthy controls. Individuals with HLA-DRB1*1301 (OR = 
      0.24, P < 0.001) and HLA-DQB1*0201 (OR = 0.49, P = 0.002) alleles have a 
      protective effect against primary DCM. Two haplotypes were associated with 
      increased risk of primary DCM: DRB1*0401/DQB1*0302 (OR = 4.53, P = 0.002) and 
      DRB1*0401/DQB1*0401 (OR = 9.42, P = 0.004). In conclusion, our data suggest that 
      the variation in class II HLA alleles could be a genetic factor involved in the 
      susceptibility to primary DCM in the Tunisian population.
FAU - Mahjoub, S
AU  - Mahjoub S
AD  - Unite d'Epidemiologie Genetique et Moleculaire, Faculte de Medecine de Tunis, 
      Tunis, Tunisia.
FAU - Mehri, S
AU  - Mehri S
FAU - Ghazouani, E
AU  - Ghazouani E
FAU - Ouarda, F
AU  - Ouarda F
FAU - Boussada, R
AU  - Boussada R
FAU - Zaroui, A
AU  - Zaroui A
FAU - Mechmeche, R
AU  - Mechmeche R
FAU - Hammami, M
AU  - Hammami M
FAU - Ben Arab, S
AU  - Ben Arab S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100128
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04:01 antigen)
SB  - IM
MH  - Cardiomyopathy, Dilated/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Tunisia
EDAT- 2010/02/09 06:00
MHDA- 2010/09/25 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/09/25 06:00 [medline]
AID - TAN1432 [pii]
AID - 10.1111/j.1399-0039.2009.01432.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Jun;75(6):679-83. doi: 10.1111/j.1399-0039.2009.01432.x. 
      Epub 2010 Jan 28.