PMID- 20137082
OWN - NLM
STAT- MEDLINE
DCOM- 20100518
LR  - 20211020
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 8
DP  - 2010 Feb 5
TI  - Pathological complete response induced by first-line chemotherapy with single 
      agent docetaxel in a patient with advanced non small cell lung cancer.
PG  - 8
LID - 10.1186/1477-7819-8-8 [doi]
AB  - BACKGROUND: Defining the optimal treatment for patients with inoperable non small 
      cell lung cancer (NSCLC), presenting with metastatic mediastinal lymph nodes, is 
      challenging. Nevertheless, preoperative chemotherapy or radiotherapy might offer 
      a chance for these patients for radical surgical resection and, possibly, 
      complete recovery. CASE PRESENTATION: A 62-year old man with IIIA-N2 inoperable 
      NSCLC was treated with first-line single agent docetaxel. A platinum-based 
      treatment, though considered more active, was ruled out because of renal 
      impairment. The patient tolerated the treatment very well and, although his 
      initial response was not impressive, after 14 cycles he obtained a complete 
      clinical response, which was confirmed pathologically after he underwent surgical 
      lobectomy. CONCLUSION: In non-operable NSCLC patients not eligible for a 
      platinum-based treatment, single-agent docetaxel can provide complete pathologic 
      responses. Failure to obtain a response after the first few cycles should not 
      automatically discourage to continue treatment.
FAU - Riccardi, Ferdinando
AU  - Riccardi F
AD  - UOC Oncologia, Ospedale Cardarelli, Napoli, Italy. nando.riccardi@alice.it
FAU - Di Lorenzo, Giuseppe
AU  - Di Lorenzo G
FAU - Buonerba, Carlo
AU  - Buonerba C
FAU - Monaco, Guglielmo
AU  - Monaco G
FAU - Monaco, Roberto
AU  - Monaco R
FAU - Rizzo, Mimma
AU  - Rizzo M
FAU - Scagliarini, Sarah
AU  - Scagliarini S
FAU - Scognamiglio, Florinda
AU  - Scognamiglio F
FAU - Di Napoli, Marilena
AU  - Di Napoli M
FAU - Carteni', Giacomo
AU  - Carteni' G
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100205
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Taxoids)
RN  - 15H5577CQD (Docetaxel)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy/pathology/surgery
MH  - Combined Modality Therapy
MH  - Docetaxel
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Pneumonectomy
MH  - Remission Induction
MH  - Taxoids/*therapeutic use
MH  - Treatment Outcome
PMC - PMC2825189
EDAT- 2010/02/09 06:00
MHDA- 2010/05/19 06:00
PMCR- 2010/02/05
CRDT- 2010/02/09 06:00
PHST- 2009/11/12 00:00 [received]
PHST- 2010/02/05 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/05/19 06:00 [medline]
PHST- 2010/02/05 00:00 [pmc-release]
AID - 1477-7819-8-8 [pii]
AID - 10.1186/1477-7819-8-8 [doi]
PST - epublish
SO  - World J Surg Oncol. 2010 Feb 5;8:8. doi: 10.1186/1477-7819-8-8.