PMID- 20137159
OWN - NLM
STAT- MEDLINE
DCOM- 20111006
LR  - 20161018
IS  - 1009-2137 (Print)
IS  - 1009-2137 (Linking)
VI  - 18
IP  - 1
DP  - 2010 Feb
TI  - [Voltage-dependent anion channel and hematological malignancies].
PG  - 255-61
AB  - Voltage-dependent anion channel(VDAC)is mainly located on the outer mitochondrial 
      membrane. High-resolution atomic force microscopy topography shows an eye-shaped 
      VDAC with 3.8 nm x 2.7 nm pore dimensions. New work suggests pore formation by 
      the assembly of homo-oligomers and supramolecule of VDAC or hetero oligomers 
      composed of VDAC and pro-apoptotic proteins, such as Bax. The oligomeric VDAC 
      pore allows for release of cytochrome C. Thus, VDAC plays a central role in the 
      cell life and apoptosis. It has been shown that the hexokinase (HK)-VDAC1 
      interaction is critical for preventing induction of apoptosis in tumor cells. 
      VDACs are expressed more highly in cancer cells than normal cells, thus can be 
      used as the target in chemotherapy for cancer. VDAC is also involved in 
      pathogenesis of hematological malignancies such as myeloma and chronic 
      lymphocytic leukemia. Following identification of sequence and structure of VDAC, 
      studies have focused on VDAC as important pharmacological target for new 
      anticancer therapy. To induce apoptosis, agents directly interact with VDAC or 
      detach HK from VDAC to disrupt the anti-apoptosis activity of VDAC-HK 
      interaction, such as methyl jasmonate (MJ) and VDAC1-based peptides. In this 
      review, the function, modulation, structure and location of the VDAC, progress of 
      its researches in hematological malignancies and potential as targets of 
      anti-cancer drugs are summarized.
FAU - Sun, Yan
AU  - Sun Y
AD  - Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, 
      100050, Beijing, China.
FAU - Chen, Ye
AU  - Chen Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhongguo Shi Yan Xue Ye Xue Za Zhi
JT  - Zhongguo shi yan xue ye xue za zhi
JID - 101084424
RN  - 0 (Voltage-Dependent Anion Channels)
SB  - IM
MH  - *Hematologic Neoplasms/metabolism
MH  - Humans
MH  - Voltage-Dependent Anion Channels/chemistry/*metabolism
EDAT- 2010/02/09 06:00
MHDA- 2011/10/07 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2011/10/07 06:00 [medline]
AID - 1009-2137(2010)01-0255-07 [pii]
PST - ppublish
SO  - Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Feb;18(1):255-61.