PMID- 20138162
OWN - NLM
STAT- MEDLINE
DCOM- 20101122
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1323
DP  - 2010 Apr 6
TI  - Influence of CGS 21680, a selective adenosine A(2A) receptor agonist, on NMDA 
      receptor function and expression in the brain of Huntington's disease mice.
PG  - 184-91
LID - 10.1016/j.brainres.2010.01.080 [doi]
AB  - The effect of chronic treatment with the selective adenosine A(2A) receptor 
      agonist CGS 21680 on N-Methyl-d-Aspartate (NMDA) receptor function and expression 
      has been studied in the striatum and cortex of R6/2 mice, a genetic mouse model 
      of Huntington's disease (HD). Starting from 8weeks of age, R6/2 and wild type 
      (WT) mice were treated daily with CGS 21680 (0.5mg/kg i.p.) for 3weeks and the 
      expression levels of NMDA receptor subunits were then evaluated. In addition, to 
      study CGS 21680-induced changes in NMDA receptor function, NMDA-induced toxicity 
      in corticostriatal slices from both R6/2 and WT mice was investigated. We found 
      that CGS 21680 increased NR2A subunit expression and the NR2A/NR2B ratio in the 
      cortex of R6/2 mice, having no effect in WT mice. In the striatum, CGS 21680 
      reduced NR1 expression in both R6/2 and WT mice while the effect on NR2A and 
      NR2/NR2B expression was genotype-dependent, reducing and increasing their 
      expression in WT and R6/2 mice, respectively. On the contrary, NMDA-induced 
      toxicity in corticostriatal slices was not modified by the treatment in WT or HD 
      mice. These results demonstrate that in vivo activation of A(2A) receptors 
      modulates the subunit composition of NMDA receptors in the brain of HD mice.
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Ferrante, Antonella
AU  - Ferrante A
AD  - Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di 
      Sanita, Viale Regina Elena, 299, 00161, Rome, Italy.
FAU - Martire, Alberto
AU  - Martire A
FAU - Armida, Monica
AU  - Armida M
FAU - Chiodi, Valentina
AU  - Chiodi V
FAU - Pezzola, Antonella
AU  - Pezzola A
FAU - Potenza, Rosa Luisa
AU  - Potenza RL
FAU - Domenici, Maria Rosaria
AU  - Domenici MR
FAU - Popoli, Patrizia
AU  - Popoli P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100204
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Adenosine A2 Receptor Agonists)
RN  - 0 (Phenethylamines)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 120225-54-9 (2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*analogs & derivatives/pharmacology
MH  - Adenosine A2 Receptor Agonists/pharmacology
MH  - Animals
MH  - Blotting, Western
MH  - Cerebral Cortex/*drug effects/metabolism/physiopathology
MH  - Corpus Striatum/*drug effects/metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Electrophysiology
MH  - Female
MH  - Huntington Disease/*metabolism/physiopathology
MH  - Male
MH  - Mice
MH  - Neurons/drug effects/physiology
MH  - Phenethylamines/*pharmacology
MH  - Protein Subunits/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Statistics, Nonparametric
EDAT- 2010/02/09 06:00
MHDA- 2010/12/14 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/12/17 00:00 [received]
PHST- 2010/01/27 00:00 [revised]
PHST- 2010/01/28 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/12/14 06:00 [medline]
AID - S0006-8993(10)00234-9 [pii]
AID - 10.1016/j.brainres.2010.01.080 [doi]
PST - ppublish
SO  - Brain Res. 2010 Apr 6;1323:184-91. doi: 10.1016/j.brainres.2010.01.080. Epub 2010 
      Feb 4.