PMID- 20138202
OWN - NLM
STAT- MEDLINE
DCOM- 20100706
LR  - 20131121
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 48
IP  - 5
DP  - 2010 May
TI  - Vitamin E modulates reproductive toxicity of pyrethroid lambda-cyhalothrin in 
      male rabbits.
PG  - 1152-9
LID - 10.1016/j.fct.2010.02.002 [doi]
AB  - The objective of the current study was to analyze the reproductive toxicity 
      caused by lambda-cyhalothrin (LCT) in male rabbits, and to evaluate the possible 
      protective effect of vitamin E (Vit. E) as antioxidant. Animals were orally 
      administered their respective doses of LCT every other day and given drinking 
      water supplemented with vitamin E for 16 weeks. Results showed that semen quality 
      was deteriorated following treatment with LCT. Also, testosterone levels, body 
      weight (BW), feed intake (FI), and relative testes (RTW) and epididymis (REW) 
      weights were significantly decreased. Concentrations of thiobarbituric 
      acid-reactive substances (TBARS) were significantly increased in seminal plasma 
      of rabbits treated with LCT compared with control. While, activities of 
      glutathione S-transferase (GST), transaminases and acid phosphatase (AcP) were 
      significantly decreased. Vitamin E alone significantly increased testosterone 
      levels, BW, FI, RTW, REW, semen characteristics and seminal plasma enzymes, and 
      decreased the levels of TBARS. Also, the present study showed that vitamin E 
      might be effective against LCT-induced reproductive toxicity. It was suggested 
      that LCT exerted a significant adverse effect on reproductive performance of male 
      rabbits. Furthermore, vitamin E antagonized the toxic effects of LCT and improved 
      semen quality of male rabbit.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Yousef, Mokhtar I
AU  - Yousef MI
AD  - Department of Home Economic, Faculty of Specific Education, Alexandria 
      University, Alexandria, Egypt. yousefmokhtar@yahoo.com
LA  - eng
PT  - Journal Article
DEP - 20100204
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Enzymes)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 1406-18-4 (Vitamin E)
RN  - 3XMK78S47O (Testosterone)
RN  - V0V73PEB8M (cyhalothrin)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Body Weight/drug effects
MH  - Enzymes/blood
MH  - Epididymis/drug effects/pathology
MH  - Fungicides, Industrial/*toxicity
MH  - Infertility, Male/blood/chemically induced/*prevention & control
MH  - Male
MH  - Nitriles/*toxicity
MH  - Organ Size/drug effects
MH  - Oxidative Stress
MH  - Pyrethrins/*toxicity
MH  - Rabbits
MH  - Semen/chemistry/drug effects
MH  - Sperm Motility/drug effects
MH  - Spermatozoa/drug effects/physiology
MH  - Testis/drug effects/metabolism/pathology
MH  - Testosterone/blood
MH  - Thiobarbituric Acid Reactive Substances/analysis/metabolism
MH  - Vitamin E/*pharmacology
EDAT- 2010/02/09 06:00
MHDA- 2010/07/07 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2010/01/20 00:00 [revised]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/07/07 06:00 [medline]
AID - S0278-6915(10)00087-6 [pii]
AID - 10.1016/j.fct.2010.02.002 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2010 May;48(5):1152-9. doi: 10.1016/j.fct.2010.02.002. Epub 
      2010 Feb 4.