PMID- 20138879
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20161125
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 584
IP  - 6
DP  - 2010 Mar 19
TI  - Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in 
      Liver X receptor-dependent and -independent manners.
PG  - 1143-8
LID - 10.1016/j.febslet.2010.02.006 [doi]
AB  - Oxysterols activating liver X receptors (LXRs) repress expression of 
      pro-inflammatory genes and have anti-inflammatory effects. Here, we show for the 
      first time that bone marrow-derived murine mast cells (BMMCs) predominantly 
      express LXRbeta. 25-hydroxycholesterol, a representative LXR activating 
      oxysterol, suppressed IL-6 production and degranulation response in BMMCs 
      following engagement of high-affinity IgE receptor (FcepsilonRI). Interestingly, 
      25-hydroxycholesterol reduced cell-surface FcepsilonRI expression by inhibiting 
      assembly of FcepsilonRIalpha and FcepsilonRIbeta. We demonstrate that LXR 
      activation was involved in the suppression of IL-6 production in BMMCs, but that 
      reduced FcepsilonRI expression and degranulation response was mediated in an 
      LXR-independent manner.
CI  - Copyright 2010 Federation of European Biochemical Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Nunomura, Satoshi
AU  - Nunomura S
AD  - Division of Molecular Cell Immunology and Allergology, Advanced Medical Research 
      Center, Nihon University Graduate School of Medical Science, Tokyo, Japan.
FAU - Endo, Kaori
AU  - Endo K
FAU - Makishima, Makoto
AU  - Makishima M
FAU - Ra, Chisei
AU  - Ra C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100209
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Cholestanols)
RN  - 0 (Hydroxycholesterols)
RN  - 0 (Interleukin-6)
RN  - 0 (LY 295427)
RN  - 0 (Liver X Receptors)
RN  - 0 (Orphan Nuclear Receptors)
RN  - 0 (Receptors, IgE)
RN  - 0 (Sterols)
RN  - 767JTD2N31 (25-hydroxycholesterol)
SB  - IM
MH  - Animals
MH  - Antibody Affinity/drug effects
MH  - Bone Marrow Cells/drug effects/immunology/metabolism/physiology
MH  - Cell Degranulation/drug effects
MH  - Cells, Cultured
MH  - Cholestanols/pharmacology
MH  - Down-Regulation/drug effects
MH  - Hydroxycholesterols/pharmacology
MH  - Interleukin-6/metabolism
MH  - Liver X Receptors
MH  - Mast Cells/*drug effects/immunology/metabolism/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Orphan Nuclear Receptors/agonists/metabolism/*physiology
MH  - Receptors, IgE/metabolism/*physiology
MH  - Signal Transduction/drug effects/physiology
MH  - Sterols/*pharmacology
EDAT- 2010/02/09 06:00
MHDA- 2010/04/27 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/11/06 00:00 [received]
PHST- 2010/01/08 00:00 [revised]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - S0014-5793(10)00100-6 [pii]
AID - 10.1016/j.febslet.2010.02.006 [doi]
PST - ppublish
SO  - FEBS Lett. 2010 Mar 19;584(6):1143-8. doi: 10.1016/j.febslet.2010.02.006. Epub 
      2010 Feb 9.