PMID- 20139404
OWN - NLM
STAT- MEDLINE
DCOM- 20110222
LR  - 20151119
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 25
IP  - 8
DP  - 2010 Aug
TI  - Midazolam or diazepam administration during electroencephalography helps to 
      diagnose subacute sclerosing panencephalitis (SSPE).
PG  - 994-9
LID - 10.1177/0883073809357239 [doi]
AB  - Although diagnostic contribution of intravenous diazepam administration during 
      electroencephalography (EEG) recording in subacute sclerosing panencephalitis has 
      been known, no another drug with less potential side effects has been studied in 
      this procedure. In this study, diazepam is compared with midazolam in 25 subacute 
      sclerosing panencephalitis-diagnosed children and 10 children with subacute 
      sclerosing panencephalitis-suggesting symptoms, normal EEG findings and no 
      certain diagnosis. Neither midazolam nor diazepam affected typical periodic 
      slow-wave complexes. However, in the patients with atypical EEG abnormalities, 
      midazolam, like diazepam, attenuated sharp or sharp-and-slow waves, and therefore 
      made the identification of periodic slow-wave paroxysms easier. In the patients 
      with normal EEGs, both midazolam and diazepam revealed typical periodic complexes 
      on EEG recording in the same 3 patients. Cerebrospinal fluid examination verified 
      the diagnosis of subacute sclerosing panencephalitis. The findings suggest that 
      midazolam or diazepam administration increases the contribution of EEG recording 
      in atypical cases with subacute sclerosing panencephalitis.
FAU - Yilmaz, Kutluhan
AU  - Yilmaz K
AD  - Department of Pediatrics, Gaziantep University, Faculty of Medicine, Gaziantep, 
      Turkey. drkutluhan@yahoo.com
FAU - Sahin, Derya Aydin
AU  - Sahin DA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20100205
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
RN  - 0 (Biomarkers)
RN  - 0 (GABA Modulators)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - R60L0SM5BC (Midazolam)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/analysis/cerebrospinal fluid
MH  - Brain/drug effects/pathology/physiopathology
MH  - Child
MH  - Child, Preschool
MH  - *Diazepam/pharmacology
MH  - Electroencephalography/*drug effects/*methods
MH  - Evoked Potentials/drug effects/physiology
MH  - Female
MH  - GABA Modulators/pharmacology
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Midazolam/pharmacology
MH  - Predictive Value of Tests
MH  - Subacute Sclerosing Panencephalitis/*diagnosis/*physiopathology
EDAT- 2010/02/09 06:00
MHDA- 2011/02/23 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2011/02/23 06:00 [medline]
AID - 0883073809357239 [pii]
AID - 10.1177/0883073809357239 [doi]
PST - ppublish
SO  - J Child Neurol. 2010 Aug;25(8):994-9. doi: 10.1177/0883073809357239. Epub 2010 
      Feb 5.