PMID- 20140129 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20100208 LR - 20220330 IS - 1976-3026 (Electronic) IS - 1738-3684 (Print) IS - 1738-3684 (Linking) VI - 6 IP - 4 DP - 2009 Dec TI - Decreased serum brain-derived neurotrophic factor levels in elderly korean with dementia. PG - 299-305 LID - 10.4306/pi.2009.6.4.299 [doi] AB - OBJECTIVE: The primary purpose of this study was to investigate the differences in the serum brain-derived neurotrophic factor (BDNF) level between elderly Korean people over 65 years with and without dementia. METHODS: 171 individuals over 65 years were enrolled in this study. Screening for cognitive impairments was carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). One hundred thirty-two subjects scored below 1.5 standard deviations (SD) of the mean MMSE-KC score, and these were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease, Korean version (CERAD-K) and the Geriatric Depression Scale (GDS). The Clinical Dementia Rating Scale (CDRS) and the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) diagnostic criteria were used for further evaluation. Subjects with a CDRS score of 1 or higher were classified as having Alzheimer's disease (AD), and subjects with a CDRS score of 0.5 were classified as having a mild cognitive impairment (MCI). Subjects with a CDRS score of 0 were classified as having aging-associated cognitive decline (AACD). Serum BDNF levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. RESULTS: The serum BDNF levels were significantly lower in the subjects with MCI and AD compared with the healthy controls (p<0.01). A significant correlation was found between the total MMSE-KC score and serum BDNF level (r=0.295; p<0.01). However, no significant correlation was observed between the severity of MMSE-KC and the total GDS score. A significant difference was found in the total score of GDS between the AACD group and subjects with AD (p<0.05). CONCLUSION: This study suggested that BDNF might be involved in the pathophysiology of cognitive decline in elderly people. FAU - Lee, Jung Goo AU - Lee JG AD - Department of Psychiatry, Dong Suh Mental Hospital and Paik Institute for Clinical Research, Inje University, Busan, Korea. FAU - Shin, Bae Sub AU - Shin BS FAU - You, Young Sun AU - You YS FAU - Kim, Ji Eun AU - Kim JE FAU - Yoon, Sung Wook AU - Yoon SW FAU - Jeon, Dong Wook AU - Jeon DW FAU - Baek, Jun Hyung AU - Baek JH FAU - Park, Sung Woo AU - Park SW FAU - Kim, Young Hoon AU - Kim YH LA - eng PT - Journal Article DEP - 20091111 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC2808800 OTO - NOTNLM OT - Alzheimer's disease OT - Brain-derived neurotrophic factor OT - Depression OT - Mild cognitive impairment EDAT- 2010/02/09 06:00 MHDA- 2010/02/09 06:01 PMCR- 2009/12/01 CRDT- 2010/02/09 06:00 PHST- 2009/08/10 00:00 [received] PHST- 2009/10/15 00:00 [revised] PHST- 2009/10/29 00:00 [accepted] PHST- 2010/02/09 06:00 [entrez] PHST- 2010/02/09 06:00 [pubmed] PHST- 2010/02/09 06:01 [medline] PHST- 2009/12/01 00:00 [pmc-release] AID - 10.4306/pi.2009.6.4.299 [doi] PST - ppublish SO - Psychiatry Investig. 2009 Dec;6(4):299-305. doi: 10.4306/pi.2009.6.4.299. Epub 2009 Nov 11.