PMID- 20140679
OWN - NLM
STAT- MEDLINE
DCOM- 20100727
LR  - 20211020
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 99
IP  - 5
DP  - 2010 May
TI  - Serum profiles of monocyte chemoattractant protein-1 as a biomarker for patients 
      recovering from myocardial infarction.
PG  - 315-22
LID - 10.1007/s00392-010-0122-1 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays a key role in the 
      pathogenesis of atherosclerosis and has been proposed as a biomarker for patients 
      with cardiovascular disease. METHODS: To assess its clinical usefulness, serum 
      MCP-1 concentrations were measured in patients with ST-elevation myocardial 
      infarction (MI) at admission, immediately after percutaneous coronary 
      intervention (PCI), at 24 h, and after 6 months. RESULTS: We found no differences 
      in MCP-1 concentrations between patients with acute MI, patients with stable 
      coronary artery disease and healthy individuals. Although median MCP-1 
      concentrations in patients with MI were similar at admission and after 6 months, 
      there were significant differences between individuals in how MCP-1 levels 
      changed with time. As demonstrated by comparing baseline quartiles of MCP-1, the 
      levels of MCP-1 tended to increase in patients with low MCP-1 concentration at 
      admission, and decrease in patients with initially high MCP-1 levels. We found an 
      inverse correlation between MCP-1 concentration at baseline and the time to 
      reperfusion, and detected a significant decrease in MCP-1 concentration 
      immediately after PCI. We also observed lower MCP-1 concentrations over time in 
      patients who developed restenosis within 6 months. However, we did not confirm 
      the association between MCP-1 concentrations at baseline and a number of 
      previously implicated demographic, clinical and laboratory criteria. CONCLUSIONS: 
      Our data demonstrate some new aspects of MCP-1 measurement in patients with MI, 
      but do not corroborate many earlier observations.
FAU - Korybalska, Katarzyna
AU  - Korybalska K
AD  - Department of Pathophysiology, Poznan University of Medical Sciences, 
      Swiecickiego 6, 60-781, Poznan, Poland.
FAU - Pyda, Malgorzata
AU  - Pyda M
FAU - Grajek, Stefan
AU  - Grajek S
FAU - Lanocha, Magdalena
AU  - Lanocha M
FAU - Breborowicz, Andrzej
AU  - Breborowicz A
FAU - Witowski, Janusz
AU  - Witowski J
LA  - eng
PT  - Journal Article
DEP - 20100207
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Diagnosis, Computer-Assisted/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/*diagnosis
MH  - Recovery of Function
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2010/02/09 06:00
MHDA- 2010/07/28 06:00
CRDT- 2010/02/09 06:00
PHST- 2009/10/13 00:00 [received]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/07/28 06:00 [medline]
AID - 10.1007/s00392-010-0122-1 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2010 May;99(5):315-22. doi: 10.1007/s00392-010-0122-1. Epub 
      2010 Feb 7.