PMID- 20140850
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20221207
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 118
IP  - 6
DP  - 2010 Jun
TI  - Genetic variation in the G-50T polymorphism of the cytochrome P450 epoxygenase 
      CYP2J2 gene and the risk of younger onset type 2 diabetes among Chinese 
      population: potential interaction with body mass index and family history.
PG  - 346-52
LID - 10.1055/s-0029-1243604 [doi]
AB  - BACKGROUND: Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis 
      of biologically active CIS-epoxyeicosatrienoic acids (EETs). EETs have been 
      suggested to modulate PPAR-gamma and PPAR-alpha transcription activity and play a 
      role in stimulus-secretion coupling in pancreatic beta cells. Genetic 
      abnormalities in the expression of CYP2J enzymes may play a role in the 
      pathogenesis of type 2 diabetes mellitus (T2DM). Our objective was to investigate 
      CYP2J2 G-50T polymorphism (rs890293) in association with insulin resistance 
      markers and T2DM in a Chinese population. METHODS: A total of 1 747 Chinese T2DM 
      patients and 994 non-diabetic subjects were studied. The CYP2J2 G-50T 
      polymorphism was determined by a restriction fragment-length polymorphism 
      polymerase chain reaction. RESULTS: Neither the CYP2J2 genotype distribution nor 
      allele frequency differed between the control subjects and the T2DM patients. 
      However, among diabetics, subjects with a younger age at diagnosis (AAD; <40 
      years) had significantly higher T variant frequency than those with an AAD>/=40 
      years. When diabetic patients were stratified by their AAD in 10-year intervals, 
      the trend was significantly linear among age grades. A significant interaction 
      between the CYP2J2 T variant and younger onset diabetic subjects with positive 
      family diabetes history, and BMI>/=27 kg/m (2) were observed to have the highest 
      risk of diabetes and younger onset diabetics with the T variant had higher 
      homeostasis model assessment estimate of insulin resistance (HOMA-IR) and 
      HOMA-beta values than their GG genotype counterparts. Plasma concentrations of 
      stable EET metabolites were significantly lower in individuals with the G-50T SNP 
      in younger onset diabetics. CONCLUSION: These data suggest that age of onset, 
      family history, and obesity may modify the association between the CYP2J2 G-50T 
      polymorphism and T2DM risk. CYP2J2 G-50T polymorphism may contribute to the 
      pathogenesis of T2DM, partially by effects on insulin resistance, in patients 
      with younger onset T2DM.
CI  - (c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York.
FAU - Wang, C-P
AU  - Wang CP
AD  - Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou 
      University, Kaohsiung, Taiwan.
FAU - Hung, W-C
AU  - Hung WC
FAU - Yu, T-H
AU  - Yu TH
FAU - Chiu, C-A
AU  - Chiu CA
FAU - Lu, L-F
AU  - Lu LF
FAU - Chung, F-M
AU  - Chung FM
FAU - Hung, C-H
AU  - Hung CH
FAU - Shin, S-J
AU  - Shin SJ
FAU - Chen, H-J
AU  - Chen HJ
FAU - Lee, Y-J
AU  - Lee YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100205
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (CYP2J2 protein, human)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - EC 1.13.- (Oxygenases)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2J2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Asian People/genetics
MH  - Body Mass Index
MH  - China
MH  - Cytochrome P-450 CYP2J2
MH  - Cytochrome P-450 Enzyme System/*genetics
MH  - Diabetes Mellitus, Type 2/enzymology/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Insulin Resistance/genetics
MH  - Medical History Taking
MH  - Obesity/genetics
MH  - Oxygenases/genetics
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Assessment
EDAT- 2010/02/09 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/02/09 06:00
PHST- 2010/02/09 06:00 [entrez]
PHST- 2010/02/09 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1055/s-0029-1243604 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2010 Jun;118(6):346-52. doi: 
      10.1055/s-0029-1243604. Epub 2010 Feb 5.