PMID- 20141237
OWN - NLM
STAT- MEDLINE
DCOM- 20100427
LR  - 20100209
IS  - 1175-0561 (Print)
IS  - 1175-0561 (Linking)
VI  - 11
IP  - 2
DP  - 2010
TI  - A rare lymphoma in a patient with amyopathic dermatomyositis.
PG  - 151-5
LID - 10.2165/11530170-000000000-00000 [doi]
AB  - A 37-year-old Caucasian woman was evaluated for a photosensitive dermatitis. A 
      positive anti-nuclear antibody with a titer of 1 : 1280 and a speckled pattern 
      was noted and she was diagnosed with subacute cutaneous lupus erythematosus 
      (SCLE). Although the initial dermatologic diagnosis was SCLE, a skin biopsy 
      suggested the additional possibility of dermatomyositis because of increased 
      dermal mucin. We began following her at the request of the dermatology 
      department, and a diagnosis of amyopathic dermatomyositis was made based on the 
      lack of objective muscle weakness, normal muscle enzymes, negative 
      double-stranded DNA, SSA/SSB, and RNP/Smith antibody panel, and especially on the 
      cutaneous examination findings. A malignancy evaluation included a normal CT scan 
      of her chest, abdomen, and pelvis, esophagogastroduodenoscopy, colonoscopy, 
      mammography, pelvic ultrasound, Papanicolaou smear, and endometrial biopsy. She 
      developed vaginal bleeding 1 year after the onset of her skin manifestations. 
      Repeat gynecologic evaluation, including cervical biopsy, revealed a large B-cell 
      cervical lymphoma. Amyopathic dermatomyositis and lymphoma of the cervix are both 
      rare conditions. Our case emphasizes the importance of considering underlying 
      malignancy at the time of diagnosis and while the patient is followed clinically. 
      Additionally, the clinician must remain vigilant in evaluating any new clinical 
      changes in follow-up care. To our knowledge, this is the first documented case of 
      lymphoma of the cervix in the setting of amyopathic dermatomyositis.
FAU - Ledwich, Lindsay J
AU  - Ledwich LJ
AD  - Department of Rheumatology, Geisinger Medical Center, Danville, Pennsylvania 
      17822, USA.
FAU - Olenginski, Thomas P
AU  - Olenginski TP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - New Zealand
TA  - Am J Clin Dermatol
JT  - American journal of clinical dermatology
JID - 100895290
SB  - IM
MH  - Adult
MH  - Dermatomyositis/*diagnosis/pathology
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/diagnosis
MH  - Lymphoma, B-Cell/*diagnosis/pathology
MH  - Uterine Cervical Neoplasms/*diagnosis/pathology
EDAT- 2010/02/10 06:00
MHDA- 2010/04/28 06:00
CRDT- 2010/02/10 06:00
PHST- 2010/02/10 06:00 [entrez]
PHST- 2010/02/10 06:00 [pubmed]
PHST- 2010/04/28 06:00 [medline]
AID - 10 [pii]
AID - 10.2165/11530170-000000000-00000 [doi]
PST - ppublish
SO  - Am J Clin Dermatol. 2010;11(2):151-5. doi: 10.2165/11530170-000000000-00000.