PMID- 20141285
OWN - NLM
STAT- MEDLINE
DCOM- 20100628
LR  - 20170623
IS  - 1939-0084 (Electronic)
IS  - 0735-7044 (Linking)
VI  - 124
IP  - 1
DP  - 2010 Feb
TI  - Caloric restriction alters seizure disposition and behavioral profiles in 
      seizure-prone (fast) versus seizure-resistant (slow) rats.
PG  - 106-114
LID - 10.1037/a0018307 [doi]
AB  - Caloric restriction (CR), primarily known for extending life span, has proven 
      anticonvulsant in several seizure models and antiepileptogenic in a strain of 
      inherently seizure susceptible mice. Our animal model consisted of a 
      seizure-prone (Fast) strain that naturally exhibits 
      attention-deficit/hyperactivity disorder (ADHD)-like behaviors and a comparison 
      seizure-resistant (Slow) strain; we evaluated CR's effect on the typical seizure 
      sensitivities and behavioral profiles of each strain. Fast and Slow rats were fed 
      ad libitum or were calorically restricted to 80% of free-feeding body weight. 
      Rats were then tested in the open field (hyperactivity), Morris water maze 
      (learning and attention), and restraint (impulsivity) paradigms and finally 
      kindled from the amygdala. Ultimately, CR abolished signs of abnormal 
      hyperactivity in the Fast strain and retarded their kindling rates, making it the 
      first manipulation to demonstrate an antiepileptogenic effect in this animal 
      model. CR also shortened seizure durations in fully kindled Slow rats but had no 
      effect on their kindling rates, implying a differential effect of CR on genotype. 
      These results clearly endorse further investigation into the potential benefits 
      of CR for both epilepsy and ADHD.
CI  - (c) 2009 APA, all rights reserved.
FAU - Azarbar, Ataa
AU  - Azarbar A
AD  - Institute of Neuroscience, Life Sciences Research Center, Carleton University.
FAU - McIntyre, Dan C
AU  - McIntyre DC
AD  - Institute of Neuroscience, Life Sciences Research Center, Carleton University.
FAU - Gilby, Krista L
AU  - Gilby KL
AD  - Institute of Neuroscience, Life Sciences Research Center, Carleton University.
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
SB  - IM
MH  - Animals
MH  - Attention Deficit Disorder with Hyperactivity/diet therapy/*physiopathology
MH  - Behavior, Animal
MH  - Caloric Restriction/*methods
MH  - Disease Models, Animal
MH  - Exploratory Behavior/physiology
MH  - Impulsive Behavior/physiopathology
MH  - Kindling, Neurologic/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Rats
MH  - Seizures/diet therapy/*genetics/physiopathology
EDAT- 2010/02/10 06:00
MHDA- 2010/06/29 06:00
CRDT- 2010/02/10 06:00
PHST- 2010/02/10 06:00 [entrez]
PHST- 2010/02/10 06:00 [pubmed]
PHST- 2010/06/29 06:00 [medline]
AID - 2010-01915-002 [pii]
AID - 10.1037/a0018307 [doi]
PST - ppublish
SO  - Behav Neurosci. 2010 Feb;124(1):106-114. doi: 10.1037/a0018307.