PMID- 20142027
OWN - NLM
STAT- MEDLINE
DCOM- 20100907
LR  - 20220321
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 16
IP  - 2
DP  - 2010 Feb
TI  - Patients' self-assessed functional status in heart failure by New York Heart 
      Association class: a prognostic predictor of hospitalizations, quality of life 
      and death.
PG  - 150-6
LID - 10.1016/j.cardfail.2009.08.010 [doi]
AB  - BACKGROUND: Clinician-assigned New York Heart Association (NYHA) class is an 
      established predictor of outcomes in heart failure. This study aims to test 
      whether patients' self-assessment of functional status by NYHA class predicts 
      hospital admissions, quality of life, and mortality. METHODS AND RESULTS: This 
      was an observational study within a randomized controlled trial. A total of 293 
      adult patients diagnosed with heart failure were recruited after an emergency 
      admission at 3 acute hospitals in Norfolk, UK. Outcome measures included number 
      of emergency admissions over 6 months, self-assessed quality of life measured 
      with the Minnesota Living with Heart Failure questionnaire (MLHFQ) and EQ-5D at 6 
      months, and deaths up to 20 months' follow-up. Patients were grouped into 3 NYHA 
      groups (I/II, III, and IV) based on patients' self-assigned NYHA class (SA-NYHA). 
      A Poisson model indicated an increased readmission rate associated with higher 
      SA-NYHA class (adjusted rate ratio 1.21; 95% CI 1.04-1.41; P=.02). Higher SA-NYHA 
      class at baseline predicted worse quality of life at 6 months' follow-up (P=.002 
      for MLHFQ; P=.047 for EQ-5D), and was associated with higher mortality rate 
      (adjusted hazard ratio 1.84; 95% CI 1.10-3.06; P=.02). CONCLUSIONS: SA-NYHA class 
      is predictive of hospitalization, quality of life, and mortality among patients 
      with heart failure.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Holland, Richard
AU  - Holland R
AD  - School of Medicine, Health Policy and Practice, University of East Anglia, 
      Norwich, UK. r.holland@uea.ac.uk
FAU - Rechel, Boika
AU  - Rechel B
FAU - Stepien, Karolina
AU  - Stepien K
FAU - Harvey, Ian
AU  - Harvey I
FAU - Brooksby, Iain
AU  - Brooksby I
LA  - eng
GR  - PG/02/171/British Heart Foundation/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20091022
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Attitude to Death
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*classification/*diagnosis/psychology
MH  - *Hospitalization/trends
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - New York
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - *Quality of Life/psychology
MH  - *Self-Assessment
MH  - Severity of Illness Index
MH  - *Societies, Medical
PMC - PMC2817782
EDAT- 2010/02/10 06:00
MHDA- 2010/09/08 06:00
PMCR- 2010/02/01
CRDT- 2010/02/10 06:00
PHST- 2009/04/23 00:00 [received]
PHST- 2009/08/21 00:00 [revised]
PHST- 2009/08/31 00:00 [accepted]
PHST- 2010/02/10 06:00 [entrez]
PHST- 2010/02/10 06:00 [pubmed]
PHST- 2010/09/08 06:00 [medline]
PHST- 2010/02/01 00:00 [pmc-release]
AID - S1071-9164(09)01045-8 [pii]
AID - 10.1016/j.cardfail.2009.08.010 [doi]
PST - ppublish
SO  - J Card Fail. 2010 Feb;16(2):150-6. doi: 10.1016/j.cardfail.2009.08.010. Epub 2009 
      Oct 22.