PMID- 20144314
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20221207
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 3
IP  - 4
DP  - 2009 Jul 1
TI  - Genetics factors contributing to type 2 diabetes across ethnicities.
PG  - 685-9
AB  - Type 2 diabetes mellitus (T2DM) is among the many common diseases with a strong 
      genetic component, but until recently, the variants causing this disease remained 
      largely undiscovered. With the ability to interrogate most of the variation in 
      the genome, the number of genetic variants has grown from 2 to 19 genes, many 
      with multiple variants. An additional three genes are associated primarily with 
      fasting glucose rather than T2DM. Despite the plethora of new markers, the 
      individual effect is uniformly small, and the cumulative effect explains little 
      of the genetic risk for T2DM. Furthermore, the success is largely restricted to 
      European populations. Despite success in mapping genes in Asian populations, 
      success in United States minorities, particularly African Americans, has been 
      limited. The genetic findings highlight the role of the beta cell in diabetes 
      pathogenesis, but much remains to be discovered before genetic prediction and 
      individualized medicine can become a reality for this disease.
CI  - Copyright 2009 Diabetes Technology Society.
FAU - Elbein, Steven C
AU  - Elbein SC
AD  - University of Arkansas for Medical Sciences, Little Rock, and Central Arkansas 
      Veterans Healthcare System, Little Rock, Arkansas, USA. ElbeinStevenC@uams.edu
LA  - eng
GR  - R01 DK039311/DK/NIDDK NIH HHS/United States
GR  - R01 DK039311-24/DK/NIDDK NIH HHS/United States
GR  - DK039311/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20090701
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
SB  - IM
MH  - Black or African American/genetics
MH  - Diabetes Mellitus, Type 2/*ethnology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genome, Human
MH  - Humans
MH  - Precision Medicine
MH  - White People/genetics
PMC - PMC2769959
EDAT- 2010/02/11 06:00
MHDA- 2010/06/03 06:00
PMCR- 2010/07/01
CRDT- 2010/02/11 06:00
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - dst.3.4.0685 [pii]
AID - 10.1177/193229680900300412 [doi]
PST - epublish
SO  - J Diabetes Sci Technol. 2009 Jul 1;3(4):685-9. doi: 10.1177/193229680900300412.