PMID- 20145991
OWN - NLM
STAT- MEDLINE
DCOM- 20100916
LR  - 20211020
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 30
IP  - 5
DP  - 2010 Jul
TI  - Losartan improved respiratory function and coenzyme Q content in brain 
      mitochondria of young spontaneously hypertensive rats.
PG  - 751-8
LID - 10.1007/s10571-010-9501-4 [doi]
AB  - Increased production of free radicals and impairment of mitochondrial function 
      are important factors in the pathogenesis of hypertension. This study examined 
      the impact of hypertension on mitochondrial respiratory chain function, coenzyme 
      Q(9) (CoQ(9)), coenzyme Q(10) (CoQ(10)), and alpha-tocopherol content in brain 
      mitochondria, and the effect of blockade of angiotensin II type 1 receptors 
      (AT1R) in the prehypertensive period on these parameters. In addition, blood 
      pressure, heart and brain weight to body weight ratios, and the geometry of the 
      basilar artery supplying the brain were evaluated. In the 9th week blood pressure 
      and heart weight/body weight ratio were significantly increased and brain 
      weight/body weight ratio was significantly decreased in spontaneously 
      hypertensive rats (SHR) when compared to Wistar rats (WR). The cross-sectional 
      area of the basilar artery was increased in SHR. Glutamate-supported respiration, 
      the rate of ATP production, and concentrations of CoQ(9), CoQ(10), and 
      alpha-tocopherol were decreased in SHR. The succinate-supported function and 
      cytochrome oxidase activity were not changed. The treatment of SHR with losartan 
      (20 mg/kg/day) from 4th to 9th week of age exerted preventive effect against 
      hypertension, heart and arterial wall hypertrophy, and brain weight/body weight 
      decline. After the therapy, the rate of ATP production and the concentration of 
      CoQ increased in comparison to untreated SHR. The impairment of energy production 
      and decreased level of lipid-soluble antioxidants in brain mitochondria as well 
      as structural alterations in the basilar artery may contribute to increased 
      vulnerability of brain tissue in hypertension. Long-term treatment with AT1R 
      blockers may prevent brain dysfunction in hypertension.
FAU - Sumbalova, Z
AU  - Sumbalova Z
AD  - Pharmacobiochemical Laboratory of Third Department of Internal Medicine, Faculty 
      of Medicine, Comenius University, Spitalska 24, 81372 Bratislava, Slovak 
      Republic. zuzana.sumbalova@zoznam.sk
FAU - Kucharska, J
AU  - Kucharska J
FAU - Kristek, F
AU  - Kristek F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100210
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Angiotensin II Type 1 Receptor Blockers)
RN  - 0 (Antioxidants)
RN  - 0 (Glutamates)
RN  - 03L9OT429T (Rotenone)
RN  - 1339-63-5 (Ubiquinone)
RN  - AB6MNQ6J6L (Succinic Acid)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EJ27X76M46 (coenzyme Q10)
RN  - H4N855PNZ1 (alpha-Tocopherol)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Aging/*drug effects
MH  - Angiotensin II Type 1 Receptor Blockers/*pharmacology
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Brain/drug effects/*metabolism
MH  - Cell Respiration/drug effects
MH  - Electron Transport/drug effects
MH  - Electron Transport Complex IV/metabolism
MH  - Glutamates/metabolism
MH  - Losartan/*pharmacology
MH  - Mitochondria/*drug effects/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Wistar
MH  - Rotenone/pharmacology
MH  - Succinic Acid/metabolism
MH  - Ubiquinone/analogs & derivatives/*metabolism
MH  - alpha-Tocopherol/metabolism
EDAT- 2010/02/11 06:00
MHDA- 2010/09/18 06:00
CRDT- 2010/02/11 06:00
PHST- 2009/10/05 00:00 [received]
PHST- 2010/01/27 00:00 [accepted]
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/09/18 06:00 [medline]
AID - 10.1007/s10571-010-9501-4 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2010 Jul;30(5):751-8. doi: 10.1007/s10571-010-9501-4. Epub 
      2010 Feb 10.