PMID- 20146002
OWN - NLM
STAT- MEDLINE
DCOM- 20100813
LR  - 20211020
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 26
IP  - 5
DP  - 2010 Jun
TI  - Low-dose CT and cardiac MR for the diagnosis of coronary artery disease: accuracy 
      of single and combined approaches.
PG  - 579-90
LID - 10.1007/s10554-010-9595-2 [doi]
AB  - To prospectively compare the diagnostic performance of low-dose computed 
      tomography coronary angiography (CTCA) and cardiac magnetic resonance imaging 
      (CMR) and combinations thereof for the diagnosis of significant coronary 
      stenoses. Forty-three consecutive patients with known or suspected coronary 
      artery disease underwent catheter coronary angiography (CA), dual-source CTCA 
      with prospective electrocardiography-gating, and cardiac CMR (1.5 Tesla). The 
      following tests were analyzed: (1) low-dose CTCA, (2) adenosine stress-rest 
      perfusion-CMR, (3) late gadolinium enhancement (LGE), (4) perfusion-CMR and LGE, 
      (5) low-dose CTCA combined with perfusion-CMR, (5) low-dose CTCA combined with 
      late gadolinium-enhancement, (6) low-dose CTCA combined with perfusion-CMR and 
      LGE. CA served as the standard of reference. CA revealed >50% diameter stenoses 
      in 68/129 (57.7%) coronary arteries in 29/43 (70%) patients. In the patient-based 
      analysis, sensitivity, specificity, NPV and PPV of low-dose CTCA for the 
      detection of significant stenoses were 100, 92.9, 100 and 96.7%, respectively. 
      For perfusion-CMR and LGE, sensitivity, specificity, NPV, PPV, and accuracy were 
      89.7, 100, 82.4, and 100%, respectively. In the artery-based analysis, 
      sensitivity and NPV of low-dose CTCA was significantly (P < 0.05) higher than 
      that of perfusion-CMR and LGE. All combinations of low-dose CTCA and 
      perfusion-CMR and/or LGE did not improve the diagnostic performance when compared 
      to low-dose CTCA alone. Taking CA as standard of reference, low-dose CTCA 
      outperforms CMR with regard to sensitivity and NPV, whereas CMR is more specific 
      and has a higher PPV than low-dose CTCA.
FAU - Scheffel, Hans
AU  - Scheffel H
AD  - Institute of Diagnostic Radiology, University Hospital Zurich, Raemistr 100, 
      8091, Zurich, Switzerland. hans.scheffel@usz.ch
FAU - Stolzmann, Paul
AU  - Stolzmann P
FAU - Alkadhi, Hatem
AU  - Alkadhi H
FAU - Azemaj, Naim
AU  - Azemaj N
FAU - Plass, Andre
AU  - Plass A
FAU - Baumueller, Stephan
AU  - Baumueller S
FAU - Desbiolles, Lotus
AU  - Desbiolles L
FAU - Leschka, Sebastian
AU  - Leschka S
FAU - Kozerke, Sebastian
AU  - Kozerke S
FAU - Falk, Volkmar
AU  - Falk V
FAU - Boesiger, Peter
AU  - Boesiger P
FAU - Wyss, Christophe
AU  - Wyss C
FAU - Marincek, Borut
AU  - Marincek B
FAU - Donati, Olivio F
AU  - Donati OF
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100210
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - 0 (Vasodilator Agents)
RN  - 4419T9MX03 (Iohexol)
RN  - 712BAC33MZ (iopromide)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine
MH  - Contrast Media
MH  - Coronary Angiography/*methods
MH  - Coronary Disease/*diagnosis/diagnostic imaging
MH  - Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Iohexol/analogs & derivatives
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Radiation Dosage
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Vasodilator Agents
EDAT- 2010/02/11 06:00
MHDA- 2010/08/14 06:00
CRDT- 2010/02/11 06:00
PHST- 2009/05/02 00:00 [received]
PHST- 2010/01/20 00:00 [accepted]
PHST- 2010/02/11 06:00 [entrez]
PHST- 2010/02/11 06:00 [pubmed]
PHST- 2010/08/14 06:00 [medline]
AID - 10.1007/s10554-010-9595-2 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2010 Jun;26(5):579-90. doi: 10.1007/s10554-010-9595-2. 
      Epub 2010 Feb 10.