PMID- 20149831
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20111117
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 71
IP  - 5
DP  - 2010 May
TI  - Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, 
      and HLA-G-DRB1 haplotypes in families with recurrent miscarriage.
PG  - 482-8
LID - 10.1016/j.humimm.2010.02.001 [doi]
AB  - A 14-base pair (bp) long insertion (ins)/deletion (del) polymorphism in exon 8 in 
      the 3'-untranslated region of the human leukocyte antigen (HLA)-G gene is 
      suggested to affect transcription of the gene. Carriage of the G14bp ins is 
      associated with low levels of soluble HLA-G and increases the risk of recurrent 
      miscarriage (RM). Due to existence of strong linkage disequilibrium (LD) in the 
      HLA region, the primary susceptibility genes for RM in the HLA-G region have not 
      yet been identified. HLA-A, -B, -DRB1, and -G14bp polymorphisms were investigated 
      in 29 Caucasian families with two or more siblings suffering unexplained RM. 
      Strong positive LD was detected between the G14bp ins and HLA-A*01, -A*11, -A*31, 
      -B*08, and DRB1*03, whereas strong negative LD was found between G14bp ins and 
      HLA-A*02, -A*03, and -A*24. The frequency of haplotypes with HLA-G14bp ins 
      inherited from the mother was significantly increased in probands with RM (p = 
      0.05). The increased compatibility between probands and their mothers for 
      maternal G14 ins positive haplotypes suggests that maternal-fetal compatibility 
      for chromosomal segments adjacent to HLA-G locus is a risk factor for female 
      offspring to experience RM in their later reproductive life.
CI  - Copyright 2010 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Kolte, Astrid M
AU  - Kolte AM
AD  - Fertility Clinic 4071, Rigshospitalet, Copenhagen University Hospital, 
      Copenhagen, Denmark.
FAU - Steffensen, Rudi
AU  - Steffensen R
FAU - Nielsen, Henriette S
AU  - Nielsen HS
FAU - Hviid, Thomas V
AU  - Hviid TV
FAU - Christiansen, Ole B
AU  - Christiansen OB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100219
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens
MH  - HLA-B Antigens
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - HLA-G Antigens
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Pedigree
MH  - Pregnancy
EDAT- 2010/02/13 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/02/13 06:00
PHST- 2009/08/18 00:00 [received]
PHST- 2010/01/19 00:00 [revised]
PHST- 2010/02/01 00:00 [accepted]
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - S0198-8859(10)00037-6 [pii]
AID - 10.1016/j.humimm.2010.02.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2010 May;71(5):482-8. doi: 10.1016/j.humimm.2010.02.001. Epub 2010 
      Feb 19.