PMID- 20150865
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20131121
IS  - 0172-780X (Print)
IS  - 0172-780X (Linking)
VI  - 31
IP  - 1
DP  - 2010
TI  - Effects of certain antioxidants on lipid peroxidation process in lung homogenates 
      of L thyroxine-receiving rats.
PG  - 137-46
AB  - OBJECTIVE: A possible role of antioxidants in thyreotoxicosis was investigated. 
      We examined the parameters of lipid peroxidation (LPO): conjugated dienes (CD), 
      malondialdehyde (MDA), Schiff bases (SB) in lung homogenates of male Wistar rats. 
      METHODS: Two control groups were created: Group 1 - intact animals and Group 2 - 
      animals injected with 0,9% NaCl. In Experiment I, the animals received L-thyroxin 
      (LT4) i.p. (Groups 3-7). After one week the rats received additionally: Group 4 - 
      melatonin (MEL); Group 5 - propylthiouracil (PTU); Group 6 - Ambroxol (AMB); 
      Group 7 - N-acetylocysteine (NAC). In Experiment II, the animals received only 
      antioxidants. RESULTS: In Experiment I, we noticed a significantly higher MDA and 
      SB level in Group 2, compared to that in Group 1. Moreover, we observed a 
      significantly higher MDA and SB level in Group 3, vs. that in Group 1, but SB 
      level was lower in Group 3 than in Group 2. Melatonin, PTU and NAC reduced CD; 
      PTU, AMB diminished MDA and MEL, AMB lowered SB levels as compared to Group 3. In 
      Experiment II, we observed significantly higher MDA and SB level in Group 2, vs. 
      that in Group 1. Melatonin, AMB and NAC decreased MDA and SB level, when compared 
      to Group 2 but PTU elevated MDA and SB level vs. that in Group 1. CONCLUSIONS: 1) 
      L-T4 suppresses LPO, 2) MEL, AMB and NAC protect against LPO, 3) PTU is an 
      antioxidant in thyreotoxicosis, however, when administered alone, it enhances 
      LPO, 4) stress accelerate LPO.
FAU - Wiktorska, Joanna A
AU  - Wiktorska JA
AD  - Department of Endocrine Disorders and Bone Metabolism, Medical University of 
      Lodz, Poland.
FAU - Lewinski, Andrzej
AU  - Lewinski A
FAU - Stuss, Michal
AU  - Stuss M
FAU - Nowak, Dariusz
AU  - Nowak D
FAU - Pietras, Tadeusz
AU  - Pietras T
FAU - Sewerynek, Ewa
AU  - Sewerynek E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Sweden
TA  - Neuro Endocrinol Lett
JT  - Neuro endocrinology letters
JID - 8008373
RN  - 0 (Antioxidants)
RN  - 0 (Antithyroid Agents)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Schiff Bases)
RN  - 0 (Tissue Extracts)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 200168S0CL (Ambroxol)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 721M9407IY (Propylthiouracil)
RN  - JL5DK93RCL (Melatonin)
RN  - Q51BO43MG4 (Thyroxine)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Ambroxol/pharmacology
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Antithyroid Agents/administration & dosage/pharmacology
MH  - Drug Evaluation, Preclinical
MH  - Free Radical Scavengers/pharmacology
MH  - Injections, Intraperitoneal
MH  - Lipid Peroxidation/*drug effects
MH  - Lung/*chemistry/drug effects/metabolism
MH  - Male
MH  - Malondialdehyde/analysis
MH  - Melatonin/administration & dosage/pharmacology
MH  - Propylthiouracil/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Schiff Bases/analysis
MH  - Thyroxine/*administration & dosage/pharmacology
MH  - Tissue Extracts/*metabolism
MH  - Triiodothyronine/blood
EDAT- 2010/02/13 06:00
MHDA- 2010/05/14 06:00
CRDT- 2010/02/13 06:00
PHST- 2009/07/01 00:00 [received]
PHST- 2009/12/15 00:00 [accepted]
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - NEL310110A03 [pii]
PST - ppublish
SO  - Neuro Endocrinol Lett. 2010;31(1):137-46.