PMID- 20150990
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100212
LR  - 20211020
IS  - 2040-7378 (Electronic)
IS  - 2040-7378 (Linking)
VI  - 2
DP  - 2010 Jan 5
TI  - Interleukin-18 does not influence infarct volume or functional outcome in the 
      early stage after transient focal brain ischemia in mice.
PG  - 1
LID - 10.1186/2040-7378-2-1 [doi]
AB  - Interleukin-18 (IL-18) is a proinflammatory cytokine of the interleukin-1 family 
      which is upregulated after cerebral ischemia. The functional role of IL-18 in 
      cerebral ischemia is unknown. In the present study, we compared infarct size in 
      IL-18 knock-out and wild-type mice 24 hours and 48 hours after 1-hour transient 
      middle cerebral artery occlusion (tMCAO). Moreover, the functional outcome was 
      evaluated in a modified Bederson score, foot fault test and grip test. There were 
      no significant differences in infarct size or functional outcome tests between 
      wild-type and IL-18 knock-out mice. These data indicate that the early 
      inflammatory response to cerebral ischemia does not involve IL-18, in contrast to 
      other interleukin-1 family members such as interleukin-1.
FAU - Braeuninger, Stefan
AU  - Braeuninger S
AD  - Department of Neurology, Julius-Maximilians-Universitaet Wuerzburg, 
      Josef-Schneider-Strasse 11, D-97080 Wuerzburg, Germany.
FAU - Kleinschnitz, Christoph
AU  - Kleinschnitz C
AD  - Department of Neurology, Julius-Maximilians-Universitaet Wuerzburg, 
      Josef-Schneider-Strasse 11, D-97080 Wuerzburg, Germany.
FAU - Stoll, Guido
AU  - Stoll G
AD  - Department of Neurology, Julius-Maximilians-Universitaet Wuerzburg, 
      Josef-Schneider-Strasse 11, D-97080 Wuerzburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20100105
PL  - England
TA  - Exp Transl Stroke Med
JT  - Experimental & translational stroke medicine
JID - 101519930
PMC - PMC2820471
EDAT- 2010/02/13 06:00
MHDA- 2010/02/13 06:01
PMCR- 2010/01/05
CRDT- 2010/02/13 06:00
PHST- 2009/10/15 00:00 [received]
PHST- 2010/01/05 00:00 [accepted]
PHST- 2010/02/13 06:00 [entrez]
PHST- 2010/02/13 06:00 [pubmed]
PHST- 2010/02/13 06:01 [medline]
PHST- 2010/01/05 00:00 [pmc-release]
AID - 2040-7378-2-1 [pii]
AID - 10.1186/2040-7378-2-1 [doi]
PST - epublish
SO  - Exp Transl Stroke Med. 2010 Jan 5;2:1. doi: 10.1186/2040-7378-2-1.