PMID- 20152262
OWN - NLM
STAT- MEDLINE
DCOM- 20100615
LR  - 20100215
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 662
IP  - 1
DP  - 2010 Mar 3
TI  - Determination of fluoroquinolone antibiotics in environmental water samples based 
      on magnetic molecularly imprinted polymer extraction followed by liquid 
      chromatography-tandem mass spectrometry.
PG  - 31-8
LID - 10.1016/j.aca.2010.01.001 [doi]
AB  - A simple method based on magnetic separation for selective extraction of 
      fluoroquinolones (FQs) from environmental water samples has been developed using 
      magnetic molecularly imprinted polymer (MMIP) as sorbent. The MMIP has been 
      prepared using ciprofloxacin as template molecule, methacrylic acid as functional 
      monomer, ethylene glycol dimethacrylate as cross-linking agent and Fe(3)O(4) 
      magnetite as magnetic component. The polymer has been characterized by scanning 
      electron microscopy, Fourier-transform infrared spectrometry and vibrating sample 
      magnetometry. Various parameters affecting the extraction efficiency were 
      evaluated in order to achieve optimal concentration and reduce non-specific 
      interactions. The analytes desorbed from the polymers were determined by liquid 
      chromatography-tandem mass spectrometry. The matrix effect was evaluated by using 
      different washing solvents for removing interfering compounds from the MMIPs 
      after sample loading. Under the optimal conditions, the linearity of the method 
      obtained is in the range of 20-2000 ng L(-1). The detection limits of FQs are in 
      the range of 3.2-6.2 ng L(-1). The relative standard deviations of intra- and 
      inter-day tests ranging from 2.5 to 7.2% and from 3.6 to 9.1% are obtained. In 
      all three spiked levels (20, 100 and 200 ng L(-1)), the recoveries of FQs are in 
      the range of 76.3-94.2%. The proposed method was successfully applied to 
      determine FQs including ciprofloxacin, enrofloxacin, lomefloxacin, levofloxacin, 
      fleroxacin and sparfloxacin in different water samples, such as lake water, river 
      water, primary and final sewage effluent. Ciprofloxacin and fleroxacin were found 
      in primary and final sewage effluent samples with the contents in the range of 
      26-87 ng L(-1).
CI  - Copyright 2010 Elsevier B.V. All rights reserved.
FAU - Chen, Ligang
AU  - Chen L
AD  - College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, 
      Jilin, China.
FAU - Zhang, Xiaopan
AU  - Zhang X
FAU - Xu, Yang
AU  - Xu Y
FAU - Du, Xiaobo
AU  - Du X
FAU - Sun, Xin
AU  - Sun X
FAU - Sun, Lei
AU  - Sun L
FAU - Wang, Hui
AU  - Wang H
FAU - Zhao, Qi
AU  - Zhao Q
FAU - Yu, Aimin
AU  - Yu A
FAU - Zhang, Hanqi
AU  - Zhang H
FAU - Ding, Lan
AU  - Ding L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100111
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Polymers)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Adsorption
MH  - Anti-Bacterial Agents/*analysis
MH  - Chromatography, Liquid
MH  - Fluoroquinolones/*analysis
MH  - *Magnetics
MH  - Membranes, Artificial
MH  - Molecular Imprinting/*methods
MH  - Polymers/*chemistry
MH  - Surface Properties
MH  - Tandem Mass Spectrometry
MH  - Water Pollutants, Chemical/*analysis
EDAT- 2010/02/16 06:00
MHDA- 2010/06/16 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2009/12/24 00:00 [revised]
PHST- 2010/01/04 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/06/16 06:00 [medline]
AID - S0003-2670(10)00005-X [pii]
AID - 10.1016/j.aca.2010.01.001 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2010 Mar 3;662(1):31-8. doi: 10.1016/j.aca.2010.01.001. Epub 2010 
      Jan 11.