PMID- 20153472
OWN - NLM
STAT- MEDLINE
DCOM- 20101026
LR  - 20210816
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 211
IP  - 1
DP  - 2010 Jul
TI  - ESR1 genetic variants, haplotypes and the risk of coronary heart disease and 
      ischemic stroke in the Finnish population: a prospective follow-up study.
PG  - 200-2
LID - 10.1016/j.atherosclerosis.2010.01.026 [doi]
AB  - Association of estrogen receptor 1 (ESR1) gene variants and risk of coronary 
      heart disease (CHD) and ischemic stroke was evaluated in the FINRISK-study. From 
      14,140 individuals, 2225 were selected for genotyping using a case-cohort design. 
      Time-to-event analysis showed that the CC genotype of -397T/C ERS1 gene 
      contributed to higher risk of CHD only in men (HR, 1.68, CI 1.03-2.74). The 
      -351A/G polymorphism was not independently associated with CHD. Haplotype 
      analysis of these two variants indicated that in men, haplotype TA conferred 
      lower risk of CHD (HR=0.72, CI 0.55-0.95), whereas men with haplotype CA had 1.8 
      higher risk of CHD events (CI 1.21-2.77), compared to other haplotypes. No 
      association was found with ischemic stroke. Our study suggests that the minor 
      allele -397C of the ESR1 gene confers risk of CHD among Finnish men, both in 
      homozygous state and as part of a haplotype with the -351A allele.
CI  - Copyright (c) 2010. Published by Elsevier Ireland Ltd.
FAU - Kunnas, Tarja
AU  - Kunnas T
AD  - Department of Medical Biochemistry, Medical School, University of Tampere, and 
      Research Unit of the Laboratory Centre, Tampere University Hospital, Tampere, 
      Finland. tarja.kunnas@uta.fi
FAU - Silander, Kaisa
AU  - Silander K
FAU - Karvanen, Juha
AU  - Karvanen J
FAU - Valkeapaa, Maria
AU  - Valkeapaa M
FAU - Salomaa, Veikko
AU  - Salomaa V
FAU - Nikkari, Seppo
AU  - Nikkari S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100128
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Disease/etiology/*genetics
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Finland
MH  - Haplotypes
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk
MH  - Stroke/*genetics
EDAT- 2010/02/16 06:00
MHDA- 2010/10/27 06:00
CRDT- 2010/02/16 06:00
PHST- 2009/09/02 00:00 [received]
PHST- 2009/12/18 00:00 [revised]
PHST- 2010/01/16 00:00 [accepted]
PHST- 2010/02/16 06:00 [entrez]
PHST- 2010/02/16 06:00 [pubmed]
PHST- 2010/10/27 06:00 [medline]
AID - S0021-9150(10)00074-2 [pii]
AID - 10.1016/j.atherosclerosis.2010.01.026 [doi]
PST - ppublish
SO  - Atherosclerosis. 2010 Jul;211(1):200-2. doi: 
      10.1016/j.atherosclerosis.2010.01.026. Epub 2010 Jan 28.