PMID- 2015516
OWN - NLM
STAT- MEDLINE
DCOM- 19910522
LR  - 20190719
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 26
IP  - 1
DP  - 1991 Jan
TI  - Ultrastructural and morphometric analysis of neurons in the arcuate nucleus of 
      the female rat hypothalamus following estradiol.
PG  - 181-4
AB  - Recent evidence suggests that E2 may act in the ventromedial nucleus of the 
      hypothalamus (VMN) and arcuate nucleus (ARC) through mechanisms partly unique to 
      each area. To examine this hypothesis, we investigated early and discontinuous 
      effects of E2 action on neurons within the ARC from an ultrastructural and 
      morphometric perspective. In contrast to our findings of dramatic, rapid effects 
      of E2 on the structure of VMN neurons, no changes in any of the ultrastructural 
      parameters examined, including the nucleolus, nucleus, nucleoplasm, and the 
      nuclear envelope-RER system, were observed in ARC neurons after either 2 hours of 
      E2 or a discontinuous schedule of 2 h on/7 h off/2 h on of E2. No changes were 
      noted in any of the quantitative parameters examined, including nucleolar, 
      nuclear, and somal area, nuclear shape, and nuclear envelope length after either 
      2 hours of E2 or a discontinuous schedule of 2 h on/7 h off/2 h on of E2. These 
      morphological results support the hypothesis of differential actions of E2 on 
      various E2-concentrating nuclear groups in the brain.
FAU - Jones, K J
AU  - Jones KJ
AD  - Chicago Medical School, IL 60064.
FAU - Pfaff, D W
AU  - Pfaff DW
FAU - McEwen, B S
AU  - McEwen BS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/cytology/*drug effects
MH  - Estradiol/*pharmacology
MH  - Female
MH  - Neurons/*drug effects/ultrastructure
MH  - Ovary/physiology
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0361-9230(91)90207-Z [pii]
AID - 10.1016/0361-9230(91)90207-z [doi]
PST - ppublish
SO  - Brain Res Bull. 1991 Jan;26(1):181-4. doi: 10.1016/0361-9230(91)90207-z.