PMID- 20156238
OWN - NLM
STAT- MEDLINE
DCOM- 20100927
LR  - 20161125
IS  - 1741-4520 (Electronic)
IS  - 0914-3505 (Linking)
VI  - 50
IP  - 2
DP  - 2010 Jun
TI  - Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate 
      development after palatal fusion.
PG  - 77-84
LID - 10.1111/j.1741-4520.2010.00271.x [doi]
AB  - Mouse embryos exposed to 2,3,7,8-tetrachloridedibenzo-p-dioxin (TCDD) develop 
      cleft palates and hydronephrosis. Cleft palates occur after TCDD exposure due to 
      contact and/or fusion failure. We investigated whether cleft palate can be 
      induced by dissociation of the palatine process after fusion. Pregnant mice on 
      gestational day (GD) 12 were randomly divided into two groups: one group was 
      administered through gastric tubes one dose of olive oil (control group) and the 
      other group was administered one dose of TCDD diluted with olive oil, both at a 
      dose of 40 microg/kg body weight. Embryos were removed by cesarean section from 
      pregnant mice during the palatal formation stage (GD 13-18) and the palatal form 
      was observed using a stereoscopic microscope. In TCDD-exposed embryos, palatal 
      fusion was observed on GD 14, 15 and 16 and the incidence of cleft palate was 
      100% on GD 18. Fusion rates were 17.5 +/- 15.2% and 12.4 +/- 11.8% on GD 15 and 
      16, respectively. Some palates from the TCDD-exposed mouse embryos showed clearly 
      developed cleft palate after fusion of the lateral palatine processes during 
      palatal formation. A mass of cells, which were chiefly epithelial in the fused 
      palates was observed in the TCDD-exposed mouse embryos. A decrease in E-cadherin 
      expression was observed in this mass of cells, indicating its involvement in the 
      development of cleft palate.
FAU - Imura, Hideto
AU  - Imura H
AD  - Division of Research and Treatment for Oral and Maxillofacial Congenital 
      Anomalies, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan. 
      hideto530406@yahoo.co.jp
FAU - Yamada, Tomohiro
AU  - Yamada T
FAU - Mishima, Katsuaki
AU  - Mishima K
FAU - Fujiwara, Kumiko
AU  - Fujiwara K
FAU - Kawaki, Harumi
AU  - Kawaki H
FAU - Hirata, Azumi
AU  - Hirata A
FAU - Sogawa, Norio
AU  - Sogawa N
FAU - Ueno, Takaaki
AU  - Ueno T
FAU - Sugahara, Toshio
AU  - Sugahara T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100211
PL  - Australia
TA  - Congenit Anom (Kyoto)
JT  - Congenital anomalies
JID - 9306292
RN  - 0 (Cadherins)
RN  - 0 (Polychlorinated Dibenzodioxins)
SB  - IM
MH  - Animals
MH  - Cadherins/metabolism
MH  - Cleft Palate/chemically induced/*embryology/pathology
MH  - Female
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Palate/*embryology
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Pregnancy
EDAT- 2010/02/17 06:00
MHDA- 2010/09/29 06:00
CRDT- 2010/02/17 06:00
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/09/29 06:00 [medline]
AID - CGA271 [pii]
AID - 10.1111/j.1741-4520.2010.00271.x [doi]
PST - ppublish
SO  - Congenit Anom (Kyoto). 2010 Jun;50(2):77-84. doi: 
      10.1111/j.1741-4520.2010.00271.x. Epub 2010 Feb 11.