PMID- 20156290
OWN - NLM
STAT- MEDLINE
DCOM- 20100520
LR  - 20181201
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 19
IP  - 2
DP  - 2010 Feb
TI  - Epidermal growth factor receptor gene numerical aberrations are frequent events 
      in actinic keratoses and invasive cutaneous squamous cell carcinomas.
PG  - 151-3
LID - 10.1111/j.1600-0625.2009.01028.x [doi]
AB  - Epidermal growth factor receptor (EGFR) gene amplification and protein 
      overexpression are common in several cancers. EGFR status has seldom been studied 
      in cutaneous squamous carcinomas (SCCs), or their precursors, actinic keratoses 
      (AKs). We evaluated the presence of EGFR genomic aberrations and EGFR protein 
      overexpression in 25 AKs and 35 invasive SCCs by means of fluorescence in situ 
      hybridization (FISH) and immunohistochemistry. EGFR numerical aberrations were 
      detected in 52% of AKs and 77.1% of SCCs (P = 0.042). EGFR amplification was 
      identified in 12% of AKs and 20% of SCCs. No differences regarding EGFR numerical 
      aberrations were observed when AKs with high-grade dysplasia were compared with 
      SCCs. A good correlation was observed between EGFR numerical aberrations and EGFR 
      overexpression. Our results suggest that EGFR numerical aberrations occur in the 
      early stages of epithelial carcinogenesis in skin, not playing a role in the 
      progression from low-grade SCCs into more aggressive phenotypes.
FAU - Toll, Agusti
AU  - Toll A
FAU - Salgado, Rocio
AU  - Salgado R
FAU - Yebenes, Mireia
AU  - Yebenes M
FAU - Martin-Ezquerra, Gemma
AU  - Martin-Ezquerra G
FAU - Gilaberte, Montserrat
AU  - Gilaberte M
FAU - Baro, Teresa
AU  - Baro T
FAU - Sole, Francesc
AU  - Sole F
FAU - Alameda, Francisco
AU  - Alameda F
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Pujol, Ramon Maria
AU  - Pujol RM
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics
MH  - ErbB Receptors/metabolism
MH  - Gene Dosage
MH  - *Genes, erbB-1
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratosis, Actinic/*genetics
MH  - Skin Neoplasms/*genetics
EDAT- 2010/02/17 06:00
MHDA- 2010/05/21 06:00
CRDT- 2010/02/17 06:00
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/05/21 06:00 [medline]
AID - EXD1028 [pii]
AID - 10.1111/j.1600-0625.2009.01028.x [doi]
PST - ppublish
SO  - Exp Dermatol. 2010 Feb;19(2):151-3. doi: 10.1111/j.1600-0625.2009.01028.x.