PMID- 20156513
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20100323
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 34
IP  - 3
DP  - 2010 Apr 16
TI  - The integrity of corpus callosum and cluster B personality disorders: a 
      quantitative MRI study in juvenile myoclonic epilepsy.
PG  - 516-21
LID - 10.1016/j.pnpbp.2010.02.009 [doi]
AB  - Evidence suggests increased prevalence of cluster B personality disorders (PD) 
      among patients with juvenile myoclonic epilepsy (JME), which has been associated 
      with worse seizure control and more psychosocial dysfunctions. A preliminary 
      voxel-based morphometry study demonstrated corpus callosum (CC) volume reduction 
      in patients with JME and cluster B PD, particularly in the posterior midbody and 
      isthmus. In this study we aimed to follow up these results with region of 
      interest analysis. Sixteen JME patients with cluster B PD, 38 JME patients 
      without any psychiatric disorder, and 30 demographically matched healthy controls 
      submitted to a psychiatric evaluation and a magnetic resonance imaging scan. The 
      total and regional callosal areas were obtained from the midsagittal slice using 
      a semi-automated program. Psychiatric evaluation was performed through SCID-I and 
      -II. Significant reductions in the posterior region of the CC were observed in 
      the JME with PD group relative to the other groups. These data support previous 
      findings of callosal reductions in cluster B PD, as well as a possible 
      involvement of CC in patients with JME and such personality characteristics.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Filho, Gerardo Maria de Araujo
AU  - Filho GM
AD  - Department of Neurology, Universidade Federal de Sao Paulo/UNIFESP, Sao Paulo, 
      Brazil. filho.gerardo@gmail.com
FAU - Jackowski, Andrea Parolin
AU  - Jackowski AP
FAU - Lin, Katia
AU  - Lin K
FAU - Silva, Ivaldo
AU  - Silva I
FAU - S B Guaranha, Mirian
AU  - S B Guaranha M
FAU - Guilhoto, Laura M F F
AU  - Guilhoto LM
FAU - Junior, Henrique Carrete
AU  - Junior HC
FAU - Yacubian, Elza Marcia T
AU  - Yacubian EM
FAU - Bressan, Rodrigo Affonseca
AU  - Bressan RA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100213
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Corpus Callosum/*pathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Myoclonic Epilepsy, Juvenile/complications/*pathology
MH  - Personality Disorders/complications/*pathology
MH  - Personality Inventory
MH  - Psychiatric Status Rating Scales
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2010/02/17 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/02/17 06:00
PHST- 2009/11/23 00:00 [received]
PHST- 2010/02/09 00:00 [revised]
PHST- 2010/02/09 00:00 [accepted]
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - S0278-5846(10)00056-4 [pii]
AID - 10.1016/j.pnpbp.2010.02.009 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2010 Apr 16;34(3):516-21. doi: 
      10.1016/j.pnpbp.2010.02.009. Epub 2010 Feb 13.