PMID- 20156894
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20211020
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Print)
IS  - 0031-4005 (Linking)
VI  - 125
IP  - 3
DP  - 2010 Mar
TI  - Case-control study of neurodevelopment in deformational plagiocephaly.
PG  - e537-42
LID - 10.1542/peds.2009-0052 [doi]
AB  - OBJECTIVE: We assessed the neurodevelopment of infants with and without 
      deformational plagiocephaly (DP), at an average age of 6 months. METHODS: The 
      Bayley Scales of Infant Development III (BSID-III) were administered to 235 case 
      subjects and 237 demographically similar, control participants. Three-dimensional 
      head photographs were randomized and rated for severity of deformation by 2 
      craniofacial dysmorphologists who were blinded to case status. RESULTS: We 
      excluded 2 case subjects with no photographic evidence of DP and 70 control 
      subjects who were judged to have some degree of DP. With control for age, gender, 
      and socioeconomic status, case subjects performed worse than control subjects on 
      all BSID-III scales and subscales. Case subjects' average scores on the motor 
      composite scale were approximately 10 points lower than control subjects' average 
      scores (P < .001). Differences for the cognitive and language composite scales 
      were approximately 5 points, on average (P < .001 for both scales). In subscale 
      analyses, case subjects' gross-motor deficits were greater than their fine-motor 
      deficits. Among case subjects, there was no association between BSID-III 
      performance and the presence of torticollis or infant age at diagnosis. 
      CONCLUSIONS: DP seems to be associated with early neurodevelopmental 
      disadvantage, which is most evident in motor functions. After follow-up 
      evaluations of this cohort at 18 and 36 months, we will assess the stability of 
      this finding. These data do not necessarily imply that DP causes 
      neurodevelopmental delay; they indicate only that DP is a marker of elevated risk 
      for delays. Pediatricians should monitor closely the development of infants with 
      this condition.
FAU - Speltz, Matthew L
AU  - Speltz ML
AD  - Seattle Children's Hospital, 4800 Sand Point Way, N.E., Mailstop W-3636, Seattle, 
      WA 98105, USA. mspeltz@u.washington.edu
FAU - Collett, Brent R
AU  - Collett BR
FAU - Stott-Miller, Marni
AU  - Stott-Miller M
FAU - Starr, Jacqueline R
AU  - Starr JR
FAU - Heike, Carrie
AU  - Heike C
FAU - Wolfram-Aduan, Antigone M
AU  - Wolfram-Aduan AM
FAU - King, Darcy
AU  - King D
FAU - Cunningham, Michael L
AU  - Cunningham ML
LA  - eng
GR  - 1 UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - M01 RR000037/RR/NCRR NIH HHS/United States
GR  - R01 HD046565/HD/NICHD NIH HHS/United States
GR  - UL1 RR025014/RR/NCRR NIH HHS/United States
GR  - 1 R01 HD046565/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20100215
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
SB  - IM
CIN - J Pediatr. 2010 Sep;157(3):514-5. PMID: 20727446
MH  - Case-Control Studies
MH  - *Child Development
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Plagiocephaly, Nonsynostotic/complications/*physiopathology
MH  - Severity of Illness Index
MH  - Torticollis/etiology/physiopathology
PMC - PMC3392083
MID - NIHMS386847
EDAT- 2010/02/17 06:00
MHDA- 2010/04/07 06:00
PMCR- 2012/07/09
CRDT- 2010/02/17 06:00
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
PHST- 2012/07/09 00:00 [pmc-release]
AID - peds.2009-0052 [pii]
AID - 10.1542/peds.2009-0052 [doi]
PST - ppublish
SO  - Pediatrics. 2010 Mar;125(3):e537-42. doi: 10.1542/peds.2009-0052. Epub 2010 Feb 
      15.