PMID- 20157739
OWN - NLM
STAT- MEDLINE
DCOM- 20100709
LR  - 20211020
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 25
IP  - 6
DP  - 2010 Jun
TI  - Levels of urinary transforming growth factor beta-1 in children with D+ hemolytic 
      uremic syndrome.
PG  - 1177-80
LID - 10.1007/s00467-009-1434-0 [doi]
AB  - About 25-50% of survivors of the acute phase of postdiarrheal hemolytic uremic 
      syndrome (D+ HUS) develop chronic renal disease. Transforming growth factor 
      beta-1 (TGFbeta-1) is the main fibrogenic growth factor in humans, and there is a 
      significant correlation between its levels and the grade of interstitial fibrosis 
      in chronic nephropathies. We hypothesized that increased urinary TGFbeta-1 may be 
      an early indicator of sequelae in D+ HUS patients who show no sign of renal 
      damage as determined by conventional diagnostic tests. We therefore compared the 
      levels of TGFbeta-1 in urine collected from healthy controls (HC) (n = 18) with 
      that from patients with a past history of D+ HUS (n = 39). We found that 
      TGFbeta-1 excretion was significantly higher (p < 0.001) in the patient group 
      (median level 73 pg/mg creatinine) than in the HC (median level 28 pg/mg 
      creatinine). TGFbeta-1 excretion did not correlate with age, white blood cell 
      count, length of oligoanuric period, maximum creatinine at the acute stage, or 
      length of the follow-up. Since TGFbeta-1 excretion may reflect ongoing renal 
      tissue damage, our results emphasize the need for the lifelong follow-up of 
      patients with a past history of D+ HUS, even those showing apparent recovery. 
      Long-term monitoring of this cohort is necessary to determine the clinical 
      utility of our findings.
FAU - Caletti, Maria Gracia
AU  - Caletti MG
AD  - Department of Nephrology, Prof. Dr. Juan P. Garrahan Children's Hospital, Combate 
      de los Pozos 1881, 1245 Buenos Aires, Argentina. mcaletti@garrahan.gov.ar
FAU - Balestracci, Alejandro
AU  - Balestracci A
FAU - Roy, Adriana Haydee
AU  - Roy AH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100216
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Hemolytic-Uremic Syndrome/complications/*urine
MH  - Humans
MH  - Infant
MH  - Kidney Failure, Chronic/etiology/urine
MH  - Male
MH  - Transforming Growth Factor beta1/*urine
EDAT- 2010/02/17 06:00
MHDA- 2010/07/10 06:00
CRDT- 2010/02/17 06:00
PHST- 2009/05/05 00:00 [received]
PHST- 2009/12/17 00:00 [accepted]
PHST- 2009/12/15 00:00 [revised]
PHST- 2010/02/17 06:00 [entrez]
PHST- 2010/02/17 06:00 [pubmed]
PHST- 2010/07/10 06:00 [medline]
AID - 10.1007/s00467-009-1434-0 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2010 Jun;25(6):1177-80. doi: 10.1007/s00467-009-1434-0. Epub 
      2010 Feb 16.