PMID- 20158475
OWN - NLM
STAT- MEDLINE
DCOM- 20101012
LR  - 20190823
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 17
IP  - 12
DP  - 2010
TI  - Virulence mechanisms displayed by Salmonella to impair dendritic cell function.
PG  - 1156-66
AB  - Dendritic cells (DCs) link innate and adaptive immunity by directly recognizing 
      pathogen-associated molecular patterns (PAMPs) on bacteria. DCs can capture and 
      degrade bacteria and present their antigens on MHC molecules to T cells. PAMP 
      recognition promotes DC maturation, a phenotypic change that empowers them to 
      prime naive T cells. As a result, an adaptive immune response that specifically 
      targets bacteria-derived antigens is initiated. Consequently, any impairment of 
      DC function might contribute to bacterial survival and dissemination in the host. 
      Therefore, the characterization of DC-bacteria interactions is required to 
      understand the mechanisms used by virulent bacteria to avoid adaptive immunity. 
      An example of a bacterial pathogen capable of interfering with DC function is 
      Salmonella enterica serovar Typhimurium (S. Typhimurium), which causes a 
      typhoid-like disease in mice. Virulent strains of S. Typhimurium are able to 
      differentially modulate the entrance to DCs and avoid lysosomal degradation, to 
      prevent antigen presentation on MHC molecules. These features of virulent S. 
      Typhimurium are controlled by virulence factors encoded by Salmonella 
      Pathogenicity Islands 1 and 2. Modulation of DC functions by the activity of 
      these gene products is supported by several recent studies, which have shown that 
      pathogenesis might depend on this attribute of virulent S. Typhimurium. Here we 
      discuss recent data showing that several virulence factors from Salmonella are 
      required to differentially modulate DC function and adaptive immunity in the 
      host.
FAU - Bueno, S M
AU  - Bueno SM
AD  - Departamento de Genetica Molecular y Microbiologia, Pontificia Universidad 
      Catolica de Chile, Santiago, Chile.
FAU - Riedel, C A
AU  - Riedel CA
FAU - Carreno, L J
AU  - Carreno LJ
FAU - Kalergis, A M
AU  - Kalergis AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Salmonella Infections/*microbiology
MH  - Salmonella typhimurium/*immunology/*pathogenicity
MH  - Virulence Factors/immunology
RF  - 174
EDAT- 2010/02/18 06:00
MHDA- 2010/10/13 06:00
CRDT- 2010/02/18 06:00
PHST- 2009/11/24 00:00 [received]
PHST- 2010/02/10 00:00 [accepted]
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/10/13 06:00 [medline]
AID - BSP/CMC/E-Pub/ 072 [pii]
AID - 10.2174/092986710790827825 [doi]
PST - ppublish
SO  - Curr Med Chem. 2010;17(12):1156-66. doi: 10.2174/092986710790827825.