PMID- 20159642
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220321
IS  - 1876-7591 (Electronic)
IS  - 1876-7591 (Linking)
VI  - 3
IP  - 2
DP  - 2010 Feb
TI  - Role of cardiac magnetic resonance imaging in the detection of cardiac 
      amyloidosis.
PG  - 155-64
LID - 10.1016/j.jcmg.2009.09.023 [doi]
AB  - OBJECTIVES: Our aim was to evaluate the role and mechanism of late gadolinium 
      enhancement (LGE) cardiac magnetic resonance (CMR) in identifying cardiac 
      amyloidosis (CA) and to investigate associations between LGE and clinical, 
      morphologic, functional, and biochemical features. BACKGROUND: CA can be 
      challenging to diagnose by echocardiography. Recent studies have demonstrated an 
      emerging role for LGE-CMR. METHODS: LGE-CMR was performed in 120 patients with 
      amyloidosis. Cardiac histology was available in 35 patients. The remaining 85 
      patients were divided into those with and without echocardiographic evidence of 
      CA. RESULTS: Of the 35 patients with histologically verified CA, abnormal LGE was 
      present in 34 (97%) patients and increased echocardiographic left ventricular 
      wall thickness in 32 (91%) patients. Global transmural or subendocardial LGE 
      (83%) was most common and was associated with greater interstitial amyloid 
      deposition (p = 0.03). Suboptimal myocardial nulling (8%) and patchy focal LGE 
      (6%) were also observed. LGE distribution matched the deposition pattern of 
      interstitial amyloid. Among patients without cardiac histology, LGE was present 
      in 86% of those with evidence of CA by echocardiography and in 47% of those 
      without evidence of CA by echocardiography. In patients without echocardiographic 
      evidence of CA, the presence of LGE was associated with worse clinical, 
      electrocardiographic (ECG), and cardiac biomarker profiles. In all patients, LGE 
      presence and pattern was associated with New York Heart Association functional 
      class, ECG voltage, left ventricular mass index, right ventricular wall 
      thickness, troponin-T, and B-type natriuretic peptide levels. CONCLUSIONS: LGE is 
      common in CA and detects interstitial expansion from amyloid deposition. Global 
      transmural or subendocardial LGE is most common, but suboptimal myocardial 
      nulling and focal patchy LGE are also observed. LGE-CMR may detect early cardiac 
      abnormalities in patients with amyloidosis with normal left ventricular 
      thickness. The presence and pattern of LGE is strongly associated with clinical, 
      morphologic, functional, and biochemical markers of prognosis.
CI  - 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All 
      rights reserved.
FAU - Syed, Imran S
AU  - Syed IS
AD  - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, 
      USA. syed.imran@mayo.edu
FAU - Glockner, James F
AU  - Glockner JF
FAU - Feng, Dali
AU  - Feng D
FAU - Araoz, Philip A
AU  - Araoz PA
FAU - Martinez, Matthew W
AU  - Martinez MW
FAU - Edwards, William D
AU  - Edwards WD
FAU - Gertz, Morie A
AU  - Gertz MA
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
FAU - Oh, Jae K
AU  - Oh JK
FAU - Bellavia, Diego
AU  - Bellavia D
FAU - Tajik, A Jamil
AU  - Tajik AJ
FAU - Grogan, Martha
AU  - Grogan M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - JACC Cardiovasc Imaging
JT  - JACC. Cardiovascular imaging
JID - 101467978
RN  - 0 (Biomarkers)
RN  - 0 (Contrast Media)
RN  - 84F6U3J2R6 (gadodiamide)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - JACC Cardiovasc Imaging. 2010 Feb;3(2):165-7. PMID: 20159643
MH  - Aged
MH  - Amyloidosis/*diagnosis/diagnostic imaging/pathology
MH  - Biomarkers/blood
MH  - Biopsy
MH  - Cardiomyopathies/*diagnosis/diagnostic imaging/pathology
MH  - Chi-Square Distribution
MH  - *Contrast Media
MH  - Early Diagnosis
MH  - Electrocardiography
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Ultrasonography
EDAT- 2010/02/18 06:00
MHDA- 2010/05/07 06:00
CRDT- 2010/02/18 06:00
PHST- 2008/12/17 00:00 [received]
PHST- 2009/09/03 00:00 [revised]
PHST- 2009/09/16 00:00 [accepted]
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - S1936-878X(09)00793-1 [pii]
AID - 10.1016/j.jcmg.2009.09.023 [doi]
PST - ppublish
SO  - JACC Cardiovasc Imaging. 2010 Feb;3(2):155-64. doi: 10.1016/j.jcmg.2009.09.023.