PMID- 20160369
OWN - NLM
STAT- MEDLINE
DCOM- 20100511
LR  - 20181201
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 5
IP  - 4
DP  - 2009 Oct-Dec
TI  - Budd-Chiari syndrome and heparin-induced thrombocytopenia in polycythemia vera: 
      successful treatment with repeated TIPS and interferon alpha.
PG  - 305-8
LID - 10.4103/0973-1482.59917 [doi]
AB  - Polycythemia vera (PV) is a common cause of Budd-Chiari syndrome (BCS) and portal 
      vein thrombosis (PVT). The postpartum period is a precipitating cofactor. An 
      additional heparin-induced thrombocytopenia/thrombosis (HIT/T) leads to a 
      life-threatening condition in which transjugular intrahepatic portosystemic 
      shunting (TIPS) seems to be the only life-saving procedure. We describe the case 
      of a subacute BCS and PVT in the late postpartum period. The diagnosis was 
      established using CT scan, MRI, and Doppler ultrasonography of abdominal vessels 
      and the laboratory findings were compatible with PV. After a successful creation 
      of TIPS, a HIT/T worsened the hemorrhagic and thrombotic picture. TIPS procedure 
      was successfully repeated and heparin was replaced with Fondaparinux and then 
      vitamin K antagonist. The treatment with interferon alpha-2A, started after the 
      normalization of liver functions, resulted in a complete remission within 6 
      months. The JAK2 V617F mutation clone remained undetectable after 2 years' 
      follow-up.
FAU - Akoum, Riad
AU  - Akoum R
AD  - Department of Oncology, Rizk Hospital, Beirut, Lebanon.
FAU - Mahfoud, Daniel
AU  - Mahfoud D
FAU - Ghaoui, Albert
AU  - Ghaoui A
FAU - Haddad, Nadine
AU  - Haddad N
FAU - Mahfoud, Nathalie
AU  - Mahfoud N
FAU - Farhat, Hussein
AU  - Farhat H
FAU - Khoury, Joe
AU  - Khoury J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
RN  - 0 (Anticoagulants)
RN  - 0 (Immunologic Factors)
RN  - 0 (Interferon-alpha)
RN  - 0 (Polysaccharides)
RN  - 12001-79-5 (Vitamin K)
RN  - 9005-49-6 (Heparin)
RN  - J177FOW5JL (Fondaparinux)
SB  - IM
MH  - Adult
MH  - Anticoagulants/adverse effects
MH  - Budd-Chiari Syndrome/etiology/physiopathology/*therapy
MH  - Female
MH  - Fondaparinux
MH  - Heparin/adverse effects
MH  - Humans
MH  - Immunologic Factors/*therapeutic use
MH  - Interferon-alpha/*therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Polycythemia Vera/complications/physiopathology/*therapy
MH  - Polysaccharides/therapeutic use
MH  - *Portasystemic Shunt, Transjugular Intrahepatic
MH  - Thrombocytopenia/chemically induced/complications/*therapy
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography, Doppler
MH  - Vitamin K/agonists
EDAT- 2010/02/18 06:00
MHDA- 2010/05/12 06:00
CRDT- 2010/02/18 06:00
PHST- 2010/02/18 06:00 [entrez]
PHST- 2010/02/18 06:00 [pubmed]
PHST- 2010/05/12 06:00 [medline]
AID - JCanResTher_2009_5_4_305_59917 [pii]
AID - 10.4103/0973-1482.59917 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2009 Oct-Dec;5(4):305-8. doi: 10.4103/0973-1482.59917.