PMID- 20163059
OWN - NLM
STAT- MEDLINE
DCOM- 20100316
LR  - 20221207
IS  - 0895-3988 (Print)
IS  - 0895-3988 (Linking)
VI  - 22
IP  - 5
DP  - 2009 Oct
TI  - Gene expression profile of human skeletal muscle and adipose tissue of Chinese 
      Han patients with type 2 diabetes mellitus.
PG  - 359-68
LID - 10.1016/S0895-3988(10)60012-8 [doi]
AB  - OBJECTIVE: To study the differential patterns of gene expression in skeletal 
      muscle and adipose tissue between type 2 diabetes mellitus (T2DM) patients and 
      healthy subjects using DNA microarray analysis. METHODS: T2DM patiens were 
      divided into female group, young male group and old male group. DNA microarray 
      analysis and quantitative real-time PCR were carried out to analyze the relation 
      between gene expressions and T2DM. RESULTS: The mRNA expression of 298, 578, and 
      350 genes was changed in the skeletal muscle of diabetes mellitus patients 
      compared with control subjects. The 1320, 1143, and 2847 genes were modified in 
      adipose tissue of the three groups. Among the genes surveyed, the change of 25 
      and 39 gene transcripts in skeletal muscle and adipose tissue was > or = 2 folds. 
      These differentially expressed genes were classified into 15 categories according 
      to their functions. CONCLUSION: New genes are found and T2DM can be prevented or 
      cured.
FAU - Yang, Yan-Li
AU  - Yang YL
AD  - Department of Internal Medicine, Peking Union Medical College Hospital, Peking 
      Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, 
      China.
FAU - Xiang, Ruo-Lan
AU  - Xiang RL
FAU - Yang, Chang
AU  - Yang C
FAU - Liu, Xiao-Jun
AU  - Liu XJ
FAU - Shen, Wen-Jun
AU  - Shen WJ
FAU - Zuo, Jin
AU  - Zuo J
FAU - Chang, Yong-Sheng
AU  - Chang YS
FAU - Fang, Fu-De
AU  - Fang FD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Biomed Environ Sci
JT  - Biomedical and environmental sciences : BES
JID - 8909524
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Aged
MH  - Asian People
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*metabolism
MH  - Oligonucleotide Array Sequence Analysis
EDAT- 2010/02/19 06:00
MHDA- 2010/03/17 06:00
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2010/03/17 06:00 [medline]
AID - S0895-3988(10)60012-8 [pii]
AID - 10.1016/S0895-3988(10)60012-8 [doi]
PST - ppublish
SO  - Biomed Environ Sci. 2009 Oct;22(5):359-68. doi: 10.1016/S0895-3988(10)60012-8.