PMID- 20163637
OWN - NLM
STAT- MEDLINE
DCOM- 20100527
LR  - 20131121
IS  - 1740-0929 (Electronic)
IS  - 1344-3941 (Linking)
VI  - 80
IP  - 3
DP  - 2009 Jun
TI  - Intracerebroventricular injection of L-aspartic acid and L-asparagine induces 
      sedative effects under an acute stressful condition in neonatal chicks.
PG  - 286-90
LID - 10.1111/j.1740-0929.2009.00625.x [doi]
AB  - The present study was conducted to clarify the central functions of L-aspartic 
      acid (Asp) and L-asparagine (Asn) during an acute stressful condition in chicks. 
      Intracerebroventricular (i.c.v.) injection of Asp and Asn (0.84 micromol) 
      attenuated the vocalization that normally occurs during social separation stress. 
      Asp decreased the time spent in active wakefulness and induced sedation. Asn had 
      a similar effect to Asp, although somewhat weaker. However, i.c.v. injection of 
      Asp and Asn further enhanced plasma corticosterone release under social 
      separation stress. Taken together, the i.c.v. injection of Asp and Asn has 
      sedative effects under an acute stressful condition, which does not involve the 
      hypothalamic-pituitary-adrenal axis.
FAU - Yamane, Haruka
AU  - Yamane H
AD  - Laboratory of Advanced Animal and Marine Bioresources, Graduate School of 
      Bioresources and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, 
      Japan.
FAU - Asechi, Mari
AU  - Asechi M
FAU - Tsuneyoshi, Yousuke
AU  - Tsuneyoshi Y
FAU - Kurauchi, Isao
AU  - Kurauchi I
FAU - Denbow, D Michael
AU  - Denbow DM
FAU - Furuse, Mitsuhiro
AU  - Furuse M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Anim Sci J
JT  - Animal science journal = Nihon chikusan Gakkaiho
JID - 100956805
RN  - 0 (Hypnotics and Sedatives)
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 7006-34-0 (Asparagine)
SB  - IM
MH  - Animals
MH  - Asparagine/*administration & dosage
MH  - Aspartic Acid/*administration & dosage
MH  - Behavior, Animal/*drug effects
MH  - Cerebral Ventricles
MH  - Chickens/*physiology
MH  - Hypnotics and Sedatives/*administration & dosage
MH  - Injections
MH  - Stress, Psychological/drug therapy
MH  - Vocalization, Animal/drug effects
EDAT- 2010/02/19 06:00
MHDA- 2010/05/28 06:00
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2010/02/19 06:00 [pubmed]
PHST- 2010/05/28 06:00 [medline]
AID - ASJ625 [pii]
AID - 10.1111/j.1740-0929.2009.00625.x [doi]
PST - ppublish
SO  - Anim Sci J. 2009 Jun;80(3):286-90. doi: 10.1111/j.1740-0929.2009.00625.x.