PMID- 20165558
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240405
IS  - 1876-3863 (Print)
IS  - 1876-3863 (Electronic)
VI  - 1
DP  - 2008 Jan 1
TI  - Tumor Necrosis Factor-alpha Suppresses Activation of Sustained Potassium Currents in 
      Rat Small Diameter Sensory Neurons.
PG  - 1
AB  - Tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, produces pain and 
      hyperalgesia by activating and/or sensitizing nociceptive sensory neurons. In the 
      present study, using whole-cell patch clamp techniques, the regulation of 
      potassium currents by TNF-alpha was examined in acutely dissociated small dorsal root 
      ganglion neurons. We found that acute application of TNF-alpha inhibited, in a 
      dose-dependent manner, the non-inactivating sustained potassium current without 
      changing the rapidly inactivating transient current or the kinetics of 
      steady-state inactivation. The effects of TNF-alpha on potassium currents were 
      similar to that of prostaglandin E2 as reported previously and also demonstrated 
      in the current study. Furthermore, indomethacin, a potent inhibitor for both 
      cyclo-oxygenase (COX) -1 and COX-2, completely blocked the effect of TNF-alpha on 
      potassium currents. These results suggest that TNF-alpha may sensitize or activate 
      sensory neurons by suppressing the sustained potassium current in nociceptive DRG 
      neurons, possibly via stimulating the synthesis/release of endogenous 
      prostaglandins.
FAU - Liu, Bao-Gang
AU  - Liu BG
AD  - Department of Anesthesiology, University of Arkansas for Medical Sciences, Little 
      Rock, AR.
FAU - Dobretsov, Maxim
AU  - Dobretsov M
FAU - Stimers, Joseph R
AU  - Stimers JR
FAU - Zhang, Jun-Ming
AU  - Zhang JM
LA  - eng
GR  - R01 NS045594-05/NS/NINDS NIH HHS/United States
GR  - R01 NS045594/NS/NINDS NIH HHS/United States
GR  - R01 NS039568-04/NS/NINDS NIH HHS/United States
GR  - R01 NS055860/NS/NINDS NIH HHS/United States
GR  - R01 NS039568/NS/NINDS NIH HHS/United States
GR  - R01 NS055860-02/NS/NINDS NIH HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Open Pain J
JT  - The open pain journal
JID - 101515226
PMC - PMC2822358
MID - NIHMS151472
EDAT- 2008/01/01 00:00
MHDA- 2008/01/01 00:01
PMCR- 2010/02/16
CRDT- 2010/02/19 06:00
PHST- 2010/02/19 06:00 [entrez]
PHST- 2008/01/01 00:00 [pubmed]
PHST- 2008/01/01 00:01 [medline]
PHST- 2010/02/16 00:00 [pmc-release]
AID - 10.2174/1876386300801010001 [doi]
PST - ppublish
SO  - Open Pain J. 2008 Jan 1;1:1. doi: 10.2174/1876386300801010001.