PMID- 20167361
OWN - NLM
STAT- MEDLINE
DCOM- 20100802
LR  - 20100311
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 31
IP  - 13
DP  - 2010 May
TI  - A circular cross-section PDMS microfluidics system for replication of 
      cardiovascular flow conditions.
PG  - 3459-64
LID - 10.1016/j.biomaterials.2010.01.082 [doi]
AB  - Since the inception of soft lithography, microfluidic devices for cardiovascular 
      research have been fabricated easily and cost-effectively using the soft 
      lithography method. The drawback of this method was the fabrication of 
      microchannels with rectangular cross-sections, which did not replicate the 
      circular cross-sections of blood vessels. This article presents a novel, 
      straightforward approach for the fabrication of microchannels with circular 
      cross-sections in poly(dimethylsiloxane) (PDMS), using soft lithography. The 
      method exploits the polymerization of the liquid silicone oligomer around a gas 
      stream when both of them are coaxially introduced in the microchannel with a 
      rectangular cross-section. We demonstrate (i) the ability to control the diameter 
      of circular cross-sections of microchannels from ca. 40-100 mum; (ii) the 
      fabrication of microchannels with constrictions, and (iii) the capability to grow 
      endothelial cells on the inner surface of the microchannels.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Fiddes, Lindsey K
AU  - Fiddes LK
AD  - Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, 
      Ontario M5S 3H6, Canada.
FAU - Raz, Neta
AU  - Raz N
FAU - Srigunapalan, Suthan
AU  - Srigunapalan S
FAU - Tumarkan, Ethan
AU  - Tumarkan E
FAU - Simmons, Craig A
AU  - Simmons CA
FAU - Wheeler, Aaron R
AU  - Wheeler AR
FAU - Kumacheva, Eugenia
AU  - Kumacheva E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100218
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Dimethylpolysiloxanes)
SB  - IM
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Endothelium, Vascular/cytology
MH  - Microfluidics/*instrumentation
MH  - *Regional Blood Flow
EDAT- 2010/02/20 06:00
MHDA- 2010/08/03 06:00
CRDT- 2010/02/20 06:00
PHST- 2009/11/29 00:00 [received]
PHST- 2010/01/13 00:00 [accepted]
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/08/03 06:00 [medline]
AID - S0142-9612(10)00114-6 [pii]
AID - 10.1016/j.biomaterials.2010.01.082 [doi]
PST - ppublish
SO  - Biomaterials. 2010 May;31(13):3459-64. doi: 10.1016/j.biomaterials.2010.01.082. 
      Epub 2010 Feb 18.