PMID- 20167364
OWN - NLM
STAT- MEDLINE
DCOM- 20100624
LR  - 20151119
IS  - 1532-3102 (Electronic)
IS  - 0143-4004 (Linking)
VI  - 31
IP  - 4
DP  - 2010 Apr
TI  - Gestational age and dose influence on placental transfer of 63Ni in rats.
PG  - 305-11
LID - 10.1016/j.placenta.2010.01.015 [doi]
AB  - The effects of gestational age and dose of nickel exposure on regulating and 
      influencing placental transfer were investigated. Pregnant rats on gestational 
      day (GD) 12, 15 or 20 were injected intraperitoneally with saline, 64,320 or 640 
      kBq/kg body weight of (63)Ni. Twenty-four hours after administration, samples 
      were harvested from each for measurement of radioactivity by liquid scintillation 
      counting and for autoradiography. In placenta, amniotic fluid and fetal membrane, 
      (63)Ni concentrations increased with increasing doses and gestational age. In 
      fetus, (63)Ni concentrations reached a maximum on GD 15 and then declined on GD 
      20 although they maintained a dose-dependency for each GD group. In fetal blood 
      on GD 20, (63)Ni concentration increased dose-dependently and was higher than in 
      maternal blood. The autoradiographs demonstrated that (63)Ni radioactivity was 
      located within placental basal lamina, fetal bones and most organs. These 
      findings suggest that the nickel uptake, retention and transport in placenta 
      increase dose- and gestation age-dependently, and nickel transfer through 
      placental barrier is primarily from mother into the fetus, but hardly from fetus 
      to mother.
CI  - Copyright 2010 Elsevier Ltd. All rights reserved.
FAU - Wang, X-W
AU  - Wang XW
AD  - Department of Neuroscience, Anatomy, Histology and Embryology, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, PR China.
FAU - Gu, J-Y
AU  - Gu JY
FAU - Li, Z
AU  - Li Z
FAU - Song, Y-F
AU  - Song YF
FAU - Wu, W-S
AU  - Wu WS
FAU - Hou, Y-P
AU  - Hou YP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100218
PL  - Netherlands
TA  - Placenta
JT  - Placenta
JID - 8006349
RN  - 0 (Radioisotopes)
RN  - 696BNE976J (nickel chloride)
RN  - 7OV03QG267 (Nickel)
SB  - IM
MH  - Abnormalities, Drug-Induced
MH  - Amniotic Fluid/metabolism
MH  - Animals
MH  - Autoradiography
MH  - Bone and Bones/embryology/metabolism
MH  - Extraembryonic Membranes/metabolism
MH  - Female
MH  - Fetus/metabolism
MH  - *Gestational Age
MH  - Kidney/metabolism
MH  - Maternal-Fetal Exchange
MH  - Nickel/administration & dosage/*metabolism/toxicity
MH  - Placenta/metabolism
MH  - Pregnancy
MH  - Radioisotopes/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2010/02/20 06:00
MHDA- 2010/06/25 06:00
CRDT- 2010/02/20 06:00
PHST- 2009/11/16 00:00 [received]
PHST- 2010/01/24 00:00 [revised]
PHST- 2010/01/26 00:00 [accepted]
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/06/25 06:00 [medline]
AID - S0143-4004(10)00041-X [pii]
AID - 10.1016/j.placenta.2010.01.015 [doi]
PST - ppublish
SO  - Placenta. 2010 Apr;31(4):305-11. doi: 10.1016/j.placenta.2010.01.015. Epub 2010 
      Feb 18.