PMID- 20169624
OWN - NLM
STAT- MEDLINE
DCOM- 20100514
LR  - 20211020
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 51
IP  - 5
DP  - 2010 May
TI  - Specific human leukocyte antigen class I and II alleles associated with hepatitis 
      C virus viremia.
PG  - 1514-22
LID - 10.1002/hep.23515 [doi]
AB  - Studies of human leukocyte antigen (HLA) alleles and their relation with 
      hepatitis C virus (HCV) viremia have had conflicting results. However, these 
      studies have varied in size and methods, and few large studies assessed HLA class 
      I alleles. Only one study conducted high-resolution class I genotyping. The 
      current investigation therefore involved high-resolution HLA class I and II 
      genotyping of a large multiracial cohort of U.S. women with a high prevalence of 
      HCV and HIV. Our primary analyses evaluated associations between 12 HLA alleles 
      identified through a critical review of the literature and HCV viremia in 758 
      HCV-seropositive women. Other alleles with >5% prevalence were also assessed; 
      previously unreported associations were corrected for multiple comparisons. 
      DRB1*0101 (prevalence ratio [PR] = 1.7; 95% confidence interval [CI] = 1.1-2.6), 
      B*5701 (PR=2.0; 95% CI = 1.0-3.1), B*5703 (PR = 1.7; 95% CI = 1.0-2.5), and 
      Cw*0102 (PR = 1.9; 95% CI = 1.0-3.0) were associated with the absence of HCV RNA 
      (i.e., HCV clearance), whereas DRB1*0301 (PR = 0.4; 95% CI = 0.2-0.7) was 
      associated with HCV RNA positivity. DQB1*0301 was also associated with the 
      absence of HCV RNA but only among HIV-seronegative women (PR = 3.4; 95% CI = 
      1.2-11.8). Each of these associations was among those predicted. We additionally 
      studied the relation of HLA alleles with HCV infection (serostatus) in women at 
      high risk of HCV from injection drug use (N = 838), but no significant 
      relationships were observed. CONCLUSION: HLA genotype influences the host 
      capacity to clear HCV viremia. The specific HLA associations observed in the 
      current study are unlikely to be due to chance because they were a priori 
      hypothesized.
FAU - Kuniholm, Mark H
AU  - Kuniholm MH
AD  - Department of Epidemiology and Population Health, Albert Einstein College of 
      Medicine, Bronx, NY 10461, USA. mark.kuniholm@einstein.yu.edu
FAU - Kovacs, Andrea
AU  - Kovacs A
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Xue, Xiaonan
AU  - Xue X
FAU - Marti, Darlene
AU  - Marti D
FAU - Thio, Chloe L
AU  - Thio CL
FAU - Peters, Marion G
AU  - Peters MG
FAU - Terrault, Norah A
AU  - Terrault NA
FAU - Greenblatt, Ruth M
AU  - Greenblatt RM
FAU - Goedert, James J
AU  - Goedert JJ
FAU - Cohen, Mardge H
AU  - Cohen MH
FAU - Minkoff, Howard
AU  - Minkoff H
FAU - Gange, Stephen J
AU  - Gange SJ
FAU - Anastos, Kathryn
AU  - Anastos K
FAU - Fazzari, Melissa
AU  - Fazzari M
FAU - Harris, Tiffany G
AU  - Harris TG
FAU - Young, Mary A
AU  - Young MA
FAU - Strickler, Howard D
AU  - Strickler HD
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - UO1-HD-32632/HD/NICHD NIH HHS/United States
GR  - U01 DK066116/DK/NIDDK NIH HHS/United States
GR  - UO1-AI-34989/AI/NIAID NIH HHS/United States
GR  - U01 AI035004/AI/NIAID NIH HHS/United States
GR  - R01 AI057006/AI/NIAID NIH HHS/United States
GR  - UO1-AI-35004/AI/NIAID NIH HHS/United States
GR  - U01 AI034994/AI/NIAID NIH HHS/United States
GR  - 5R01AI057006-04/AI/NIAID NIH HHS/United States
GR  - U01 AI034989-15/AI/NIAID NIH HHS/United States
GR  - UO1-AI-42590/AI/NIAID NIH HHS/United States
GR  - R01 AI057006-04/AI/NIAID NIH HHS/United States
GR  - UO1-AI-34994/AI/NIAID NIH HHS/United States
GR  - R01A1052065/PHS HHS/United States
GR  - U01 AI031834/AI/NIAID NIH HHS/United States
GR  - U01 HD032632-14/HD/NICHD NIH HHS/United States
GR  - R56 AI052065/AI/NIAID NIH HHS/United States
GR  - U01 AI035004-11S2/AI/NIAID NIH HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - U01 AI034989/AI/NIAID NIH HHS/United States
GR  - R01 AI052065/AI/NIAID NIH HHS/United States
GR  - U01 AI034994-15/AI/NIAID NIH HHS/United States
GR  - UO1-AI-34993/AI/NIAID NIH HHS/United States
GR  - R01AI057006/AI/NIAID NIH HHS/United States
GR  - L30 AI084473/AI/NIAID NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - U01 AI042590-04S1/AI/NIAID NIH HHS/United States
GR  - U01 AI031834-16/AI/NIAID NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - U01 AI034993/AI/NIAID NIH HHS/United States
GR  - UO1-AI-31834/AI/NIAID NIH HHS/United States
GR  - UL1 RR024131-04/RR/NCRR NIH HHS/United States
GR  - U01 AI034993-15/AI/NIAID NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - U01 HD032632/HD/NICHD NIH HHS/United States
GR  - U01 AI042590/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cohort Studies
MH  - Female
MH  - Hepacivirus/immunology
MH  - Hepatitis C/immunology/*virology
MH  - Hepatitis C, Chronic/immunology/*virology
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Middle Aged
MH  - RNA, Viral/analysis
MH  - Substance Abuse, Intravenous
MH  - Viremia/*immunology
PMC - PMC2946382
MID - NIHMS217837
COIS- Potential conflict of interest: Dr. Terrault has received research grants from 
      Roche, Vertex, and Human Genome Sciences. All other authors, no conflicts.
EDAT- 2010/02/20 06:00
MHDA- 2010/05/15 06:00
PMCR- 2011/05/01
CRDT- 2010/02/20 06:00
PHST- 2010/02/20 06:00 [entrez]
PHST- 2010/02/20 06:00 [pubmed]
PHST- 2010/05/15 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - 10.1002/hep.23515 [doi]
PST - ppublish
SO  - Hepatology. 2010 May;51(5):1514-22. doi: 10.1002/hep.23515.