PMID- 20169907
OWN - NLM
STAT- MEDLINE
DCOM- 20100409
LR  - 20151029
IS  - 0030-6657 (Print)
IS  - 0030-6657 (Linking)
VI  - 63
IP  - 5
DP  - 2009 Sep-Oct
TI  - [Recurrence in operated patients with laryngeal squamous cell carcinoma].
PG  - 419-28
LID - 10.1016/S0030-6657(09)70154-4 [doi]
AB  - PURPOSE: The aim of the present study was to investigate the recurrence 
      prevalence in patients with laryngeal squamous cell carcinoma (LSCC) underwent 
      surgery as primary treatment. MATERIAL: The assessed group consisted of 148 
      patients with operable LSCC underwent surgery as primary treatment between 
      1999-2002. Surgery was performed in all cases. Total laryngectomy was performed 
      in 107 (72.3%) patients and laser endoscopic tumor resection was performed in 41 
      (27.7%) patients. RESULTS: Local recurrence occurred in 18 (12.2%) patients, 
      nodal recurrence in 12 (8.1%) and both and/or remote metastases in 6 (4%) 
      patients. Altogether, recurrence was present in 36 (24.3%) patients and 111 
      (75.7%) patients had no symptoms of recurrence. Recurrence prevalence in 3-year 
      follow-up--prevalence of recurrence significantly increased with tumor's T 
      feature (p=0.04), N feature (p=0.03), progression of clinical stage (p=0.008) and 
      histological malignancy G stage (p=0.01). Recurrence prevalence in 5-year 
      follow-up--prevalence of recurrence significantly increased with tumor's T 
      feature (p=0.02), N feature (p=0.01), progression of clinical stage (p=0.003) and 
      histological malignancy G stage (p=0.002). Tumors localized in glottic area had 
      less recurrences than those localized in supraglottic area (p=0.05). There were 
      no significant dependence between recurrence type (local or nodal) and tumor's 
      clinicopathological features. Multiple factor analysis with logistic regression 
      model did not revealed simultaneous influence of many variables on recurrence's 
      presence and type. Using multiple factor analysis with Cox's regression model it 
      was proved that recurrence presence (p<0.00001) is a significant independent 
      prognostic factor in the analyzed group of patients with laryngeal carcinoma in 
      3-year follow-up. CONCLUSIONS: Recurrence prevalence depends on localization, 
      systemic progression stage, clinical progression stage, cervical lymph nodes 
      state and histological malignancy stage of tumor. Patients with local recurrence 
      have statistically significantly worse prognosis than patients with no 
      recurrence. Recurrence presence is significant independent prognostic factor in 
      3-year follow-up.
FAU - Morshed, Kamal
AU  - Morshed K
AD  - Klinika Otolaryngologii i Onkologii, Laryngologicznej Uniwersytetu Medycznego w 
      Lublinie. kamal1@op.pl
FAU - Szymanski, Marcin
AU  - Szymanski M
FAU - Zadrozniak, Marek
AU  - Zadrozniak M
FAU - Siwiec, Henryk
AU  - Siwiec H
FAU - Wawrzecka, Agnieszka
AU  - Wawrzecka A
FAU - Tarasiuk, Agnieszka
AU  - Tarasiuk A
FAU - Abushammalah, Rashad
AU  - Abushammalah R
FAU - Smolen, Agata
AU  - Smolen A
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Wznowy u pacjentow leczonych operacyjnie z powodu raka krtani.
PL  - Poland
TA  - Otolaryngol Pol
JT  - Otolaryngologia polska = The Polish otolaryngology
JID - 0404453
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*epidemiology/*surgery
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/*epidemiology/*surgery
MH  - Laryngectomy/statistics & numerical data
MH  - Lymph Nodes/pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*epidemiology/*surgery
MH  - Neoplasm Staging
MH  - Poland/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Recurrence
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2010/02/23 06:00
MHDA- 2010/04/10 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/04/10 06:00 [medline]
AID - S0030-6657(09)70154-4 [pii]
AID - 10.1016/S0030-6657(09)70154-4 [doi]
PST - ppublish
SO  - Otolaryngol Pol. 2009 Sep-Oct;63(5):419-28. doi: 10.1016/S0030-6657(09)70154-4.