PMID- 20170496 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20100609 LR - 20211020 IS - 1749-8546 (Electronic) IS - 1749-8546 (Linking) VI - 5 DP - 2010 Feb 19 TI - Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors. PG - 7 LID - 10.1186/1749-8546-5-7 [doi] AB - A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. However, the molecular basis of its clinical effectiveness remains obscure. This article reviews the in vitro and in vivo data of its estrogenic actions, particularly those mediated by estrogen receptor-beta (ERbeta). FAU - Vollmer, Gunter AU - Vollmer G AD - Molekulare Zellphysiologie & Endokrinologie, Fachrichtung Biologie, Technische Universitat Dresden, Dresden, Germany. Guenter.Vollmer@tu-dresden.de FAU - Papke, Anja AU - Papke A FAU - Zierau, Oliver AU - Zierau O LA - eng PT - Journal Article DEP - 20100219 PL - England TA - Chin Med JT - Chinese medicine JID - 101265109 PMC - PMC2837008 EDAT- 2010/02/23 06:00 MHDA- 2010/02/23 06:01 PMCR- 2010/02/19 CRDT- 2010/02/23 06:00 PHST- 2009/09/02 00:00 [received] PHST- 2010/02/19 00:00 [accepted] PHST- 2010/02/23 06:00 [entrez] PHST- 2010/02/23 06:00 [pubmed] PHST- 2010/02/23 06:01 [medline] PHST- 2010/02/19 00:00 [pmc-release] AID - 1749-8546-5-7 [pii] AID - 10.1186/1749-8546-5-7 [doi] PST - epublish SO - Chin Med. 2010 Feb 19;5:7. doi: 10.1186/1749-8546-5-7.