PMID- 20171751
OWN - NLM
STAT- MEDLINE
DCOM- 20100817
LR  - 20220318
IS  - 1879-0887 (Electronic)
IS  - 0167-8140 (Linking)
VI  - 94
IP  - 3
DP  - 2010 Mar
TI  - Limited benefit of inversely optimised intensity modulation in breast conserving 
      radiotherapy with simultaneously integrated boost.
PG  - 307-12
LID - 10.1016/j.radonc.2010.01.024 [doi]
AB  - BACKGROUND AND PURPOSE: To examine whether in breast-conserving radiotherapy (RT) 
      with simultaneously integrated boost (SIB), application of inversely planned 
      intensity-modulated radiotherapy (IMRT-SIB) instead of three-dimensional RT 
      (3D-CRT-SIB) has benefits that justify the additional costs, and to evaluate 
      whether a potential benefit of IMRT-SIB depends on specific patient 
      characteristics. MATERIAL AND METHODS: 3D-CRT-SIB and various IMRT-SIB treatment 
      plans were constructed and optimised for 30 patients with early stage left-sided 
      breast cancer. Coverage of planning target volumes (PTVs) and dose delivered to 
      organs at risk (OARs) were determined for each plan. Overlap between heart and 
      breast PTV (OHB), size of breast and boost PTVs and boost location were examined 
      in their ability to identify patients that might benefit from IMRT-SIB. RESULTS: 
      All plans had adequate PTV coverage. IMRT-SIB generally reduced dose levels 
      delivered to heart, lungs, and normal breast tissue relative to 3D-CRT-SIB. 
      However, IMRT-SIB benefit differed per patient. For many patients, comparable 
      results were obtained with 3D-CRT-SIB, while patients with OHB>1.4 cm and a 
      relatively large boost PTV volume (>125 cm(3)) gained most from the use of 
      IMRT-SIB. CONCLUSIONS: In breast-conserving RT, results obtained with 3D-CRT-SIB 
      and IMRT-SIB are generally comparable. Patient characteristics could be used to 
      identify patients that are most likely to benefit from IMRT-SIB.
CI  - (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - van der Laan, Hans Paul
AU  - van der Laan HP
AD  - Department of Radiation Oncology, University Medical Center Groningen, University 
      of Groningen, The Netherlands. h.p.van.der.laan@rt.umcg.nl
FAU - Dolsma, Wil V
AU  - Dolsma WV
FAU - Schilstra, Cornelis
AU  - Schilstra C
FAU - Korevaar, Erik W
AU  - Korevaar EW
FAU - de Bock, Geertruida H
AU  - de Bock GH
FAU - Maduro, John H
AU  - Maduro JH
FAU - Langendijk, Johannes A
AU  - Langendijk JA
LA  - eng
PT  - Journal Article
DEP - 20100218
PL  - Ireland
TA  - Radiother Oncol
JT  - Radiotherapy and oncology : journal of the European Society for Therapeutic 
      Radiology and Oncology
JID - 8407192
SB  - IM
MH  - Breast Neoplasms/*radiotherapy
MH  - Female
MH  - Humans
MH  - *Mastectomy, Segmental
MH  - *Radiotherapy Dosage
MH  - *Radiotherapy, Intensity-Modulated
EDAT- 2010/02/23 06:00
MHDA- 2010/08/18 06:00
CRDT- 2010/02/23 06:00
PHST- 2009/09/07 00:00 [received]
PHST- 2010/01/25 00:00 [revised]
PHST- 2010/01/28 00:00 [accepted]
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/08/18 06:00 [medline]
AID - S0167-8140(10)00076-9 [pii]
AID - 10.1016/j.radonc.2010.01.024 [doi]
PST - ppublish
SO  - Radiother Oncol. 2010 Mar;94(3):307-12. doi: 10.1016/j.radonc.2010.01.024. Epub 
      2010 Feb 18.