PMID- 20174772
OWN - NLM
STAT- MEDLINE
DCOM- 20100902
LR  - 20210413
IS  - 1795-990X (Electronic)
IS  - 0355-3140 (Linking)
VI  - 36
IP  - 3
DP  - 2010 May
TI  - Occupational rhinosinusitis due to etoposide, an antineoplastic agent.
PG  - 266-267
LID - 2903 [pii]
LID - 10.5271/sjweh.2903 [doi]
AB  - OBJECTIVE: This paper reports a rare case of an occupational hypersensitivity 
      reaction to an antineoplastic agent. METHODS: This is a clinical case report of a 
      45-year-old nurse who developed throat irritation and chronic nasal congestion 
      followed by sinusitis shortly after beginning work at an oncological out-patient 
      clinic. The symptoms disappeared upon leaving the clinic two years later, but 
      they returned when she resumed work at the oncology unit at Hillerod Hospital, 
      Denmark, handling chemotherapy on a daily basis. We performed in vitro histamine 
      release tests against nine suspected antineoplastic agents. RESULTS: The 
      patient's histamine release test against the antineoplastic agent etoposide was 
      positive; the other test results were negative. The histamine release test 
      against etoposide using passive sensitization was also negative. Upon leaving the 
      oncology department, the symptoms of the nurse disappeared once again. She was 
      given a diagnosis of rhinosinusitis. CONCLUSION: This case of a hypersensitivity 
      reaction to etoposide was judged to be of occupational origin. It was not clear 
      whether it was immunoglobulin E (IgE) or non-IgE mediated.
FAU - Meyer, Harald W
AU  - Meyer HW
AD  - Clinic of Occupational Medicine, Hillerod Hospital, 3400 Hillerod, Denmark. 
      hmeyer@dadlnet.dk.
FAU - Stahl Skov, Per
AU  - Stahl Skov P
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20100219
PL  - Finland
TA  - Scand J Work Environ Health
JT  - Scandinavian journal of work, environment & health
JID - 7511540
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 6PLQ3CP4P3 (Etoposide)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/poisoning
MH  - Drug Hypersensitivity/diagnosis/*etiology/immunology
MH  - Etoposide/*poisoning
MH  - Female
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Middle Aged
MH  - Occupational Diseases/*chemically induced/diagnosis/immunology
MH  - Occupational Exposure/*adverse effects
MH  - *Oncology Nursing
MH  - Rhinitis/*chemically induced/diagnosis/immunology
MH  - Sinusitis/*chemically induced/diagnosis/immunology
EDAT- 2010/02/23 06:00
MHDA- 2010/09/03 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2010/09/03 06:00 [medline]
AID - 2903 [pii]
AID - 10.5271/sjweh.2903 [doi]
PST - ppublish
SO  - Scand J Work Environ Health. 2010 May;36(3):266-267. doi: 10.5271/sjweh.2903. 
      Epub 2010 Feb 19.