PMID- 20175040
OWN - NLM
STAT- MEDLINE
DCOM- 20110106
LR  - 20100304
IS  - 1439-3964 (Electronic)
IS  - 0172-4622 (Linking)
VI  - 31
IP  - 3
DP  - 2010 Mar
TI  - Influence of chronic dietary carbohydrate supplementation on plasma cytokine 
      responses to exercise.
PG  - 207-12
LID - 10.1055/s-0029-1243645 [doi]
AB  - This study examined the influence of 28 days of dietary carbohydrate (CHO) 
      supplementation on plasma cytokine responses to cycle ergometry. Sixteen highly 
      trained male cyclists and triathletes (age: 30.6+/-5.6 y; VO2max: 64.8+/-4.7 mL x 
      kg(-1) x min(-1); mean+/-SD) participated in the study. One group (n=8) consumed 
      a higher-CHO (8.5+/-1.7 g x kg(-1) body mass.day (-1)) diet for 28 days; a second 
      group (n=8) consumed a moderate-CHO diet (5.3+/-0.4 g x kg (-1) x day (-1)). 
      Total daily energy intakes were similar between the two groups. Cytokine 
      responses to cycle ergometry were assessed prior to and again following the 
      dietary intervention period. The cycle ergometry protocol involved 100 min steady 
      state cycling at 70% VO2max followed by a time trial of approximately 30 min. 
      Athletes were provided with 15 mL x kg (-1) x h (-1) of water during each trial. 
      Blood samples were collected pre-, immediately post- and 1 h post-exercise for 
      determination of plasma glucose and pro-inflammatory (IL-6, IL-8) and 
      anti-inflammatory (IL-10, IL-1ra) cytokine concentrations. Cytokine responses to 
      cycle ergometry were not substantially altered following the 28-day higher-CHO 
      diet. In contrast, following the 28-day moderate-CHO diet, there were 
      approximately 30-50% reductions (p=0.08-0.11) in anti-inflammatory cytokine 
      responses post-exercise. These findings suggest that increased dietary CHO 
      content alone does not effectively attenuate the pro-inflammatory cytokine 
      response to exercise, however, there may be a small reduction in the 
      anti-inflammatory cytokine response.
CI  - Georg Thieme Verlag KG Stuttgart.New York.
FAU - Cox, A J
AU  - Cox AJ
AD  - University of Newcastle, School of Biomedical Sciences, Newcastle, Australia. 
      amanda.cox@newcastle.edu.au
FAU - Pyne, D B
AU  - Pyne DB
FAU - Cox, G R
AU  - Cox GR
FAU - Callister, R
AU  - Callister R
FAU - Gleeson, M
AU  - Gleeson M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20100219
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukin 1 Receptor Antagonist Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adaptation, Physiological
MH  - Adult
MH  - Bicycling/physiology
MH  - Blood Glucose
MH  - Confidence Intervals
MH  - Cytokines/*blood/drug effects
MH  - Diet
MH  - Dietary Carbohydrates/*administration & dosage
MH  - *Dietary Supplements
MH  - Ergometry
MH  - Exercise/*physiology
MH  - Exercise Tolerance
MH  - Humans
MH  - Interleukin 1 Receptor Antagonist Protein
MH  - Interleukin-10
MH  - Interleukin-6
MH  - Interleukin-8
MH  - Male
MH  - *Oxygen Consumption
MH  - Running/physiology
MH  - Swimming/physiology
MH  - Time Factors
EDAT- 2010/02/23 06:00
MHDA- 2011/01/07 06:00
CRDT- 2010/02/23 06:00
PHST- 2010/02/23 06:00 [entrez]
PHST- 2010/02/23 06:00 [pubmed]
PHST- 2011/01/07 06:00 [medline]
AID - 10.1055/s-0029-1243645 [doi]
PST - ppublish
SO  - Int J Sports Med. 2010 Mar;31(3):207-12. doi: 10.1055/s-0029-1243645. Epub 2010 
      Feb 19.