PMID- 20175455
OWN - NLM
STAT- MEDLINE
DCOM- 20100405
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 668
DP  - 2009
TI  - The role of menin in parathyroid tumorigenesis.
PG  - 79-86
AB  - Primary hyperparathyroidism is a common disorder that involves the pathological 
      enlargement of one or more parathyroid glands resulting in excessive production 
      of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to 
      be fully understood. In recent years interest has focussed on the interaction 
      between menin protein and the transforming growth factor (TGF)-beta/Smad 
      signalling pathway. In vitro experimentation has demonstrated that the presence 
      of menin is required for TGF-beta to effectively inhibit parathyroid cell 
      proliferation and PTH production. This observation correlates with the almost 
      universal occurrence of parathyroid tumors accompanying the inactivation of menin 
      in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of 
      somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter 
      aims to review the role of menin in primary hyperparathyroidism and parathyroid 
      hormone-regulation, including the influences of MEN1 gene mutations on 
      parathyroid cell proliferation, differentiation and tumorigenesis.
FAU - Davenport, Colin
AU  - Davenport C
AD  - Academic Department of Endocrinology, Beaumont Hospital and Royal College of 
      Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland.
FAU - Agha, Amar
AU  - Agha A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (MEN1 protein, human)
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Smad Proteins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Humans
MH  - Hyperparathyroidism, Primary/genetics/*metabolism/physiopathology
MH  - Multiple Endocrine Neoplasia Type 1/genetics/metabolism/physiopathology
MH  - Mutation
MH  - Parathyroid Glands/metabolism/pathology
MH  - Parathyroid Hormone/metabolism
MH  - Parathyroid Neoplasms/*metabolism/physiopathology
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Signal Transduction/physiology
MH  - Smad Proteins/metabolism
MH  - Transforming Growth Factor beta/metabolism
RF  - 26
EDAT- 2010/02/24 06:00
MHDA- 2010/04/07 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/04/07 06:00 [medline]
AID - 10.1007/978-1-4419-1664-8_8 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2009;668:79-86. doi: 10.1007/978-1-4419-1664-8_8.