PMID- 20175954
OWN - NLM
STAT- MEDLINE
DCOM- 20100521
LR  - 20191111
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 29
IP  - 2
DP  - 2010 Mar-Apr
TI  - Piriformis syndrome--an attempt to understand its pathology.
PG  - 65-70
AB  - OBJECTIVE: Gross anatomy of the hip rotators and histology of the sciatic nerves 
      in adult cadavers were studied, aiming to the identification of possible 
      pathologic changes related to the piriformis syndrome (PS). MATERIAL: 50 cadavers 
      were dissected; in 17 cases with macroscopical findings the sciatic nerves were 
      harvested (34 sciatic nerves; 17 cadavers). History of low back or leg pain was 
      not available. METHOD: Site anatomy and additional findings at the harvesting 
      sites were recorded, such as anatomical variations, adhesions, hematomas etc. All 
      nerves were additionally microscopically analyzed. In cases with findings at the 
      dissection, the contralateral unaffected nerves served as controls. All the 
      dissected nerves were conserved in 10% formalin solution, embedded in paraffin, 
      stained with Hematoxylin and Eosin (H&E) and immunolabeled with antibodies 
      against Neurofilament (NF). RESULTS: Both the H&E staining as well as the 
      performed immunohistochemistry showed, to a variable degree, significant 
      alterations in the structure of the affected nerves compared to the controls. 
      CONCLUSIONS: These findings both in the local anatomy and sciatic nerve 
      correspond to lesions that are expected in PS. Nevertheless, since this was a 
      cadaveric study, unassociated to a certain pain patient's history, results should 
      be considered and interpreted as an indication of a sciatic nerve injury in PS.
FAU - Kanakis, D N
AU  - Kanakis DN
AD  - First Department of Pathology, National and Kapodistrian University of Athens, 
      Athens, Greece. dimitrios.kanakis@uk-essen.de
FAU - Lazaris, A C
AU  - Lazaris AC
FAU - Papadopoulos, E C
AU  - Papadopoulos EC
FAU - Kallitsis, E A
AU  - Kallitsis EA
FAU - Patsouris, E S
AU  - Patsouris ES
FAU - Paraskevakou, H A
AU  - Paraskevakou HA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cadaver
MH  - Female
MH  - Hip/*anatomy & histology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/anatomy & histology
MH  - Piriformis Muscle Syndrome/*pathology
MH  - Sciatic Nerve/*anatomy & histology
EDAT- 2010/02/24 06:00
MHDA- 2010/05/22 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/05/22 06:00 [medline]
AID - 7325 [pii]
AID - 10.5414/npp29065 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2010 Mar-Apr;29(2):65-70. doi: 10.5414/npp29065.