PMID- 20176126
OWN - NLM
STAT- MEDLINE
DCOM- 20101008
LR  - 20211008
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 701
IP  - 1
DP  - 2010 Aug 14
TI  - Persistence of space radiation induced cytogenetic damage in the blood 
      lymphocytes of astronauts.
PG  - 75-9
LID - 10.1016/j.mrgentox.2010.02.007 [doi]
AB  - Cytogenetic damage was assessed in blood lymphocytes from 16 astronauts before 
      and after they participated in long-duration space missions of 3 months or more. 
      The frequency of chromosome damage was measured by fluorescence in situ 
      hybridization (FISH) chromosome painting before flight and at various intervals 
      from a few days to many months after return from the mission. For all 
      individuals, the frequency of chromosome exchanges measured within a month of 
      return from space was higher than their preflight yield. However, some 
      individuals showed a temporal decline in chromosome damage with time after 
      flight. Statistical analysis using combined data for all astronauts indicated a 
      significant overall decreasing trend in total chromosome exchanges with time 
      after flight, although this trend was not seen for all astronauts and the yield 
      of chromosome damage in some individuals actually increased with time after 
      flight. The decreasing trend in total exchanges was slightly more significant 
      when statistical analysis was restricted to data collected more than 220 days 
      after return from flight. When analysis was restricted to data collected within 
      220 days of return from the mission there was no relationship between total 
      exchanges and time. Translocation yields varied more between astronauts and there 
      was only a slight non-significant decrease with time after flight that was 
      similar for both later and earlier sampling times.
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - George, K
AU  - George K
AD  - Wyle, 1290 Hercules Drive, Houston, TX 77058, USA. Kerry.a.george@nasa.gov
FAU - Chappell, L J
AU  - Chappell LJ
FAU - Cucinotta, F A
AU  - Cucinotta FA
LA  - eng
PT  - Journal Article
DEP - 20100220
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - *Astronauts
MH  - *Chromosome Aberrations
MH  - Cosmic Radiation/*adverse effects
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphocytes/*radiation effects/ultrastructure
MH  - *Space Flight
MH  - Time Factors
EDAT- 2010/02/24 06:00
MHDA- 2010/10/12 06:00
CRDT- 2010/02/24 06:00
PHST- 2010/02/08 00:00 [received]
PHST- 2010/02/10 00:00 [accepted]
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/10/12 06:00 [medline]
AID - S1383-5718(10)00060-4 [pii]
AID - 10.1016/j.mrgentox.2010.02.007 [doi]
PST - ppublish
SO  - Mutat Res. 2010 Aug 14;701(1):75-9. doi: 10.1016/j.mrgentox.2010.02.007. Epub 
      2010 Feb 20.