PMID- 20176151
OWN - NLM
STAT- MEDLINE
DCOM- 20100913
LR  - 20211020
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Print)
IS  - 1742-7061 (Linking)
VI  - 6
IP  - 8
DP  - 2010 Aug
TI  - Poly(dimethylsiloxane) elastomers with tethered peptide ligands for cell adhesion 
      studies.
PG  - 2898-902
LID - 10.1016/j.actbio.2010.02.025 [doi]
AB  - Poly(dimethylsiloxane) (PDMS) is the choice of material for a wide range of 
      biological and non-biological applications because of its chemical inertness, 
      non-toxicity, ease of handling and commercial availability. However, PDMS 
      exhibits uncontrolled protein adsorption and cell adhesion and it has proved 
      difficult to functionalize to present bioactive ligands. We present a facile 
      strategy for functional surface modification of PDMS using commercial reagents to 
      engineer polymer brushes of oligo(ethylene glycol) methacrylate that prevent cell 
      adhesion and can be functionalized to display bioadhesive ligands. The polymer 
      brushes resist biofouling and prevent cell adhesion and bioadhesive peptides can 
      be tethered either uniformly or constrained to micropatterned domains using 
      standard peptide chemistry approaches. This approach is relevant to various 
      biomedical and biotechnological applications.
CI  - Copyright 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Wu, Yuanzi
AU  - Wu Y
AD  - Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 
      100871, People's Republic of China.
FAU - Coyer, Sean R
AU  - Coyer SR
FAU - Ma, Hongwei
AU  - Ma H
FAU - Garcia, Andres J
AU  - Garcia AJ
LA  - eng
GR  - R01 GM065918/GM/NIGMS NIH HHS/United States
GR  - R01 GM065918-07/GM/NIGMS NIH HHS/United States
GR  - R01-GM065918/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20100220
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Elastomers)
RN  - 0 (Fibronectins)
RN  - 0 (Ligands)
RN  - 0 (Peptides)
SB  - IM
MH  - Animals
MH  - Cell Adhesion/drug effects
MH  - Dimethylpolysiloxanes/*pharmacology
MH  - Elastomers/*pharmacology
MH  - Fibronectins/pharmacology
MH  - Humans
MH  - Ligands
MH  - Materials Testing/*methods
MH  - Mice
MH  - NIH 3T3 Cells
MH  - Peptides/*pharmacology
MH  - Photoelectron Spectroscopy
MH  - Surface Properties/drug effects
PMC - PMC2883028
MID - NIHMS181161
EDAT- 2010/02/24 06:00
MHDA- 2010/09/14 06:00
PMCR- 2011/08/01
CRDT- 2010/02/24 06:00
PHST- 2009/12/29 00:00 [received]
PHST- 2010/02/09 00:00 [revised]
PHST- 2010/02/16 00:00 [accepted]
PHST- 2010/02/24 06:00 [entrez]
PHST- 2010/02/24 06:00 [pubmed]
PHST- 2010/09/14 06:00 [medline]
PHST- 2011/08/01 00:00 [pmc-release]
AID - S1742-7061(10)00093-0 [pii]
AID - 10.1016/j.actbio.2010.02.025 [doi]
PST - ppublish
SO  - Acta Biomater. 2010 Aug;6(8):2898-902. doi: 10.1016/j.actbio.2010.02.025. Epub 
      2010 Feb 20.