PMID- 20178495 OWN - NLM STAT- MEDLINE DCOM- 20100602 LR - 20100224 IS - 1365-3164 (Electronic) IS - 0959-4493 (Linking) VI - 20 IP - 5-6 DP - 2009 Oct TI - Levels of house dust mite-specific serum immunoglobulin E (IgE) in different cat populations using a monoclonal based anti-IgE enzyme-linked immunosorbent assay. PG - 562-8 LID - 10.1111/j.1365-3164.2009.00840.x [doi] AB - Levels of serum immunoglobulin E (IgE) specific for the house dust mites (HDMs) Dermatophagoides farinae (DF) and Dermatophagoides pteronyssinus (DP) in 58 cats with clinical signs suggestive of atopic dermatitis (allergic dermatitis cats), 52 cats with no history of allergic or immunological disease (nonallergic cats) and 26 specific pathogen-free (SPF) cats were measured using a monoclonal anti-IgE enzyme-linked immunosorbent assay. Reactivity to both native and reduced HDM allergens was compared. SPF cats had significantly lower levels of HDM-specific serum IgE than cats with allergic dermatitis and nonallergic cats. The difference in levels of HDM-specific IgE in the serum of cats with allergic dermatitis and nonallergic cats was significant for native DF allergen, but not for native DP allergen or reduced HDM allergens. The results suggest that DF in its native form may be a significant allergen in cats with allergic dermatitis. The clinical relevance of these reactions, however, remains to be proven. FAU - Bexley, Jennifer AU - Bexley J AD - YorkTest Veterinary Services, York Science Park, York, UK. jennifer.bexley@avacta.com FAU - Hogg, Janice E AU - Hogg JE FAU - Hammerberg, Bruce AU - Hammerberg B FAU - Halliwell, Richard E W AU - Halliwell RE LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Vet Dermatol JT - Veterinary dermatology JID - 9426187 RN - 0 (Antibodies, Monoclonal) RN - 0 (Antigens, Dermatophagoides) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Animals MH - Antibodies, Monoclonal/*immunology MH - Antigens, Dermatophagoides/*immunology MH - Cat Diseases/*immunology MH - Cats MH - Dermatitis, Atopic/immunology/*veterinary MH - Enzyme-Linked Immunosorbent Assay/veterinary MH - Female MH - Immunoglobulin E/*blood MH - Male MH - Pyroglyphidae/*immunology EDAT- 2010/02/25 06:00 MHDA- 2010/06/03 06:00 CRDT- 2010/02/25 06:00 PHST- 2010/02/25 06:00 [entrez] PHST- 2010/02/25 06:00 [pubmed] PHST- 2010/06/03 06:00 [medline] AID - VDE840 [pii] AID - 10.1111/j.1365-3164.2009.00840.x [doi] PST - ppublish SO - Vet Dermatol. 2009 Oct;20(5-6):562-8. doi: 10.1111/j.1365-3164.2009.00840.x.