PMID- 20179144
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20151119
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 24
IP  - 7
DP  - 2010 Jul
TI  - In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of 
      the Mediterranean diet: a randomized controlled trial.
PG  - 2546-57
LID - 10.1096/fj.09-148452 [doi]
AB  - The aim of the study was to assess whether benefits associated with the 
      traditional Mediterranean diet (TMD) and virgin olive oil (VOO) consumption could 
      be mediated through changes in the expression of atherosclerosis-related genes. A 
      randomized, parallel, controlled clinical trial in healthy volunteers (n=90) aged 
      20 to 50 yr was performed. Three-month intervention groups were as follows: 1) 
      TMD with VOO (TMD+VOO), 2) TMD with washed virgin olive oil (TMD+WOO), and 3) 
      control with participants' habitual diet. WOO was similar to VOO, but with a 
      lower polyphenol content (55 vs. 328 mg/kg, respectively). TMD consumption 
      decreased plasma oxidative and inflammatory status and the gene expression 
      related with both inflammation [INF-gamma (INFgamma), Rho GTPase-activating 
      protein15 (ARHGAP15), and interleukin-7 receptor (IL7R)] and oxidative stress 
      [adrenergic beta(2)-receptor (ADRB2) and polymerase (DNA-directed) kappa (POLK)] 
      in peripheral blood mononuclear cells. All effects, with the exception of the 
      decrease in POLK expression, were particularly observed when VOO, rich in 
      polyphenols, was present in the TMD dietary pattern. Our results indicate a 
      significant role of olive oil polyphenols in the down-regulation of 
      proatherogenic genes in the context of a TMD. In addition, the benefits 
      associated with a TMD and olive oil polyphenol consumption on cardiovascular risk 
      can be mediated through nutrigenomic effects.
FAU - Konstantinidou, Valentini
AU  - Konstantinidou V
AD  - Cardiovascular Risk and Nutrition Research Group, Institut Municipal 
      d'Investigacio Medica (IMIM-Hospital del Mar), Centro de Investigacion Biomedica 
      Eu Red (CIBER) de Fisiopatologia de la Obesidad y Nutricion, Barcelona, Spain.
FAU - Covas, Maria-Isabel
AU  - Covas MI
FAU - Munoz-Aguayo, Daniel
AU  - Munoz-Aguayo D
FAU - Khymenets, Olha
AU  - Khymenets O
FAU - de la Torre, Rafael
AU  - de la Torre R
FAU - Saez, Guillermo
AU  - Saez G
FAU - Tormos, Maria del Carmen
AU  - Tormos Mdel C
FAU - Toledo, Estefania
AU  - Toledo E
FAU - Marti, Amelia
AU  - Marti A
FAU - Ruiz-Gutierrez, Valentina
AU  - Ruiz-Gutierrez V
FAU - Ruiz Mendez, Maria Victoria
AU  - Ruiz Mendez MV
FAU - Fito, Montserrat
AU  - Fito M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20100223
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Flavonoids)
RN  - 0 (Olive Oil)
RN  - 0 (Phenols)
RN  - 0 (Plant Oils)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Adult
MH  - Atherosclerosis/genetics
MH  - Cardiovascular Diseases/prevention & control
MH  - *Diet, Mediterranean
MH  - Down-Regulation/genetics
MH  - Flavonoids/*metabolism/therapeutic use
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Inflammation/blood
MH  - Middle Aged
MH  - Nutrigenomics/*methods
MH  - Olive Oil
MH  - Oxidation-Reduction
MH  - Phenols/*metabolism/therapeutic use
MH  - Plant Oils/administration & dosage/*metabolism/therapeutic use
MH  - Polyphenols
MH  - Young Adult
EDAT- 2010/02/25 06:00
MHDA- 2010/08/04 06:00
CRDT- 2010/02/25 06:00
PHST- 2010/02/25 06:00 [entrez]
PHST- 2010/02/25 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - fj.09-148452 [pii]
AID - 10.1096/fj.09-148452 [doi]
PST - ppublish
SO  - FASEB J. 2010 Jul;24(7):2546-57. doi: 10.1096/fj.09-148452. Epub 2010 Feb 23.