PMID- 20180645
OWN - NLM
STAT- MEDLINE
DCOM- 20100812
LR  - 20220331
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 45
IP  - 5
DP  - 2010 May
TI  - Diagnostic value of the PPI test for detection of GERD in Korean patients and 
      factors associated with PPI responsiveness.
PG  - 533-9
LID - 10.3109/00365521003650172 [doi]
AB  - OBJECTIVES: Data supporting the use of the proton pump inhibitor (PPI) test as a 
      diagnostic test of gastroesophageal reflux disease (GERD) in Asia are lacking. 
      The aims of this study were to evaluate the diagnostic characteristics of the PPI 
      test and factors associated with responsiveness to PPIs. METHODS: The PPI test 
      was evaluated using lansoprazole (30 mg bid) for two weeks. All patients 
      underwent endoscopy after symptom assessment. Patients without erosive 
      esophagitis (ERD) underwent 48 h esophageal Bravo pH monitoring. Subjects were 
      considered to be responsive to PPIs if they reported a > 50% reduction in reflux 
      symptom score. RESULTS: Seventy-three patients (M:F = 40:37, 47 +/- 13 years) 
      were enrolled. We identified 46 patients with ERD, 18 patients with nonerosive 
      reflux disease (NERD) and 9 patients without GERD. The PPI response rate was 
      higher in patients with GERD than in patients without GERD (49/64, 77% vs. 4/9, 
      44%; p < 0.05). The sensitivity, specificity, and positive and negative 
      predictive values were 77%, 56%, 92% and 25%, respectively. The PPI 
      responsiveness was 80% (37/46) in the ERD group and 67% (12/18) in the NERD 
      group. PPI response was not affected by age, sex, Helicobacter pylori, the 
      psychological characteristics or cytochrome P2C genotypes. ERD and symptom-reflux 
      association were the factors affecting PPI responsiveness. CONCLUSIONS: The PPI 
      test was modestly sensitive and specific for diagnosing GERD. However, it would 
      be useful for discriminating patients with ERD. In the NERD group, patients with 
      positive symptom-reflux association would be most benefit from PPI treatment.
FAU - Cho, Yu Kyung
AU  - Cho YK
AD  - Division of Gastroenterology, Department of Internal Medicine, The Catholic 
      University of Korea, Seoul, Korea.
FAU - Choi, Myung-Gyu
AU  - Choi MG
FAU - Lim, Chul Hyun
AU  - Lim CH
FAU - Nam, Kwan Woo
AU  - Nam KW
FAU - Chang, Jae Hyuck
AU  - Chang JH
FAU - Park, Jae Myung
AU  - Park JM
FAU - Lee, In Seok
AU  - Lee IS
FAU - Kim, Sang Woo
AU  - Kim SW
FAU - Choi, Kyu Yong
AU  - Choi KY
FAU - Chung, In-Sik
AU  - Chung IS
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
SB  - IM
MH  - *2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Chi-Square Distribution
MH  - Esophageal pH Monitoring
MH  - Esophagoscopy
MH  - Female
MH  - Gastroesophageal Reflux/*diagnosis
MH  - Humans
MH  - Korea
MH  - Lansoprazole
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - *Proton Pump Inhibitors
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
EDAT- 2010/02/26 06:00
MHDA- 2010/08/13 06:00
CRDT- 2010/02/26 06:00
PHST- 2010/02/26 06:00 [entrez]
PHST- 2010/02/26 06:00 [pubmed]
PHST- 2010/08/13 06:00 [medline]
AID - 10.3109/00365521003650172 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2010 May;45(5):533-9. doi: 10.3109/00365521003650172.